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Basic information

Name Inoue Takashi
Belonging department
Occupation name
researchmap researcher code B000003480
researchmap agency Okayama University of Science

Title

Enhancement of splenic glucose metabolism during acute malarial infection: Correlation of findings of FDG-PET imaging with pathological changes in a primate model of severe human malaria

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Author

S Kawai
E Ikeda
M Sugiyama
J Matsumoto
T Higuchi
H Zhang
N Khan
K Tomiyoshi
T Inoue
H Yamaguchi
K Katakura
K Endo
H Matsuda
M Suzuki

Summary

In the current study, to elucidate the clinical features of severe malaria, we performed whole-body positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG) of Plasmodium coatneyi-infected acute-phase Japanese macaques. The infected monkeys clearly exhibited increase in splenic FDG uptake indicating marked enhancement of glucose metabolism. The standardized uptake values (SUVs) of the spleen in the infected monkeys were significantly higher than those in the uninfected monkey. At autopsy, splenomegaly was clearly present in all infected monkeys, and histopathologic findings included hyperplasia of lymphoid follicles in white pulp, a large number of activated macrophage, and congestion of parasitized red blood cells (PRBCs) and malaria pigments in red pulp. We suggest that increase in splenic glucose uptake may thus be closely related to activation of splenic clearance system against blood-stage malarial parasites.

Magazine(name)

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Publisher

AMER SOC TROP MED & HYGIENE

Volume

74

Number Of Pages

3

StartingPage

353

EndingPage

360

Date of Issue

2006-03

Referee

Exist

Request

Not exist

Language

English

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