Academic Thesis

Basic information

Name Inoue Takashi
Belonging department
Occupation name
researchmap researcher code B000003480
researchmap agency Okayama University of Science

Title

Relationship Between Immunoglobulin Deposition and Early Lesions of Progressive Glomerulonephropathy in Young Common Marmosets

Bibliography Type

 

Author

Naoaki Yamada
Nanako Hashimoto
Junichi Kamiie
Takuya Doi
Junko Sato
Takeshi Inoue
Kinji Shirota
Minoru Tsuchitani

Summary

The authors previously investigated progressive glomerulonephropathy in 2- to 11-year-old common marmosets and characterized age-related changes of the renal glomeruli and development of tubulointerstitial lesions. In this study, immunoglobulin deposition and ultrastructural changes of the glomeruli were investigated in 5 young marmosets from 6 months to 3 years of age with pre-onset or early glomerulonephropathy. In all animals, the foot processes of podocytes were effaced, and IgM was deposited into the glomeruli. In glomeruli without glomerular basement membrane (GBM) alteration, IgM was the only immunoglobulin type deposited in the glomeruli. In cases with more advanced lesions of reticulation and thickening of GBM, IgA and IgG deposits were also observed. Therefore, the authors conclude that IgM may be the primary or earliest immunoglobulin deposited in this nephropathy, whereas IgA and IgG deposition may be connected to the progression of the glomerular lesions. IgM deposition and foot process effacement of podocytes occur early in the life of affected marmosets.

Magazine(name)

Veterinary Pathology

Publisher

SAGE Publications Inc.

Volume

55

Number Of Pages

1

StartingPage

173

EndingPage

176

Date of Issue

2018-01-01

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

ISSN

 

DOI

10.1177/0300985817712556

NAID

 

PMID

 

J-GLOBAL ID

 

arXiv ID

 

ORCID Put Code

 

DBLP ID