The present study explored how ketone body metabolism in the central and liver (peripheral) respectively relates to sleep regulation. Experiments on suppression of HMGCS2 (ketone synthase) expression in the central and liver using siRNA oligos and establishment of HMGCS2 and SCOT (ketone degrading enzyme) expression regulating mice of neurons using the tet system were carried out. As a result, the possibility that the central HMGCS 2 is involved in the sleep-depth rebound after deprivation by handling and HMGCS 2 in the liver is involved in the sleep-depth rebound after treadmill exercise has come to light.
