We investigated the contribution of central energy metabolism to higher brain functions, focusing in particular on AMPK and PPARs. PPARs and AMPK are involved in the stimulation of lipid metabolism. We used several drugs that activate PPARs and AMPK. After injection of these drugs, sleep depth and anxiety level were changed. In addition, feeding schedule can alter sleep quality by affecting metabolic function. PPARs and AMPK may play a significant role in the interaction of lipid metabolism and brain function including sleep homeostasis and common neurobehavior.
