Academic Thesis

Basic information

Name Kojima Isshu
Belonging department
Occupation name
researchmap researcher code R000055330
researchmap agency Okayama University of Science

Title

In vitro antiviral efficacy of amenamevir against feline herpesvirus 1

Bibliography Type

Joint Author

Author

Kikuiri A, Nishigaki H, Fujii H, Watanabe S, Kojima I, Morikawa S

Summary

Amenamevir (AMNV), a helicase-primase inhibitor, has recently received approval for treating human herpesvirus infections. Herein, we evaluated the efficacy of AMNV against feline herpesvirus 1 (FHV-1) in three different cell lines and compared it with that of acyclovir (ACV) and penciclovir (PCV)-nucleoside analogs currently used against FHV-1 infection. The 50% inhibitory concentrations of AMNV against FHV-1 were comparable to those of ACV in all cell lines tested, although they were 2.0 to 21.0-fold higher than those of PCV. This is the first study to have evaluated the efficacy of AMNV against animal herpesvirus, and the results suggest that AMNV could be a new option for treating FHV-1 infection with a novel mechanism of action.

Magazine(name)

J Vet Med Sci.

Publisher

Volume

87

Number Of Pages

8

StartingPage

906

EndingPage

910

Date of Issue

2025/08

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

ISSN

DOI

10.1292/jvms.25-0086.

NAID

PMID

40571578

URL

J-GLOBAL ID

arXiv ID

ORCID Put Code

DBLP ID