Expressions of vascular endothelial growth factor receptors, Flk1 and Flt1, in rat skin mast cells during development.

Miki Koh
Syunya Noguchi
Mami Araki
Hirotada Otsuka
Makoto Yokosuka
Satoshi Soeta

Vascular endothelial growth factor-A (VEGF-A) is a principal regulator of hematopoiesis as well as angiogenesis. However, the functions of VEGF-A and its receptors (VEGFRs) in the differentiation of mast cells (MCs) in the skin remain unclear. The aim of this study was to determine the expression patterns of two VEGFRs (Flk1 and Flt1) in the skin MCs during development and maturation in rats. From the 17th days of embryonic development (E17) to 1 day after birth (Day 1), most of skin MCs were immature cells containing predominant alcian blue (AB)+ rather than safranin O (SO)+ granules (AB>SO MCs). AB>SO MC proportions gradually decreased, while mature ABSO MCs had significantly decreased, and AB

The Journal of veterinary medical science

82

6

745

753

10.1292/jvms.20-0092

https://doi.org/10.1292/jvms.20-0092
https://www.ncbi.nlm.nih.gov/pubmed/32321901
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324820