Big Insulin-like Growth Factor 2-Producing Tumor in a Hypoglycemic Dog.

Syunya Noguchi
Yoshiaki Kubo
Mami Araki
Miki Koh
Yuji Hamamoto
Kyoichi Tamura
Hirotada Otsuka
Akiko Yasuda
Daigo Azakami
Masaki Michishita
Satoshi Soeta

A 10-year-old female Papillon dog that had previously developed a mammary tumor was admitted for treatment of a hypoglycemic attack. Blood examination showed severe hypoglycemia and decreased blood insulin concentration. Computed tomography indicated multiple tumors in the cranial and caudal lobes of the right lung. These tumors were resected surgically and diagnosed as pulmonary adenocarcinomas by histopathologic examination. Hypoglycemia was temporarily improved after the resection, but a hypoglycemic event occurred 2 months after the surgery. Immunohistochemistry of the tumor demonstrated the expression of insulin-like growth factor 2 in tumor cells. Western blot analysis revealed the expression of high-molecular-weight (big)-insulin-like growth factor 2 in the tumor region. Insulin-like growth factor 2 mRNA expression was also confirmed in the tumor using reverse transcription-polymerase chain reaction. These findings indicate the diagnosis of non-islet cell tumor-induced hypoglycemia caused by big-insulin-like growth factor 2 produced by the tumor in the dog. This report provides information on differentiating tumors that cause paraneoplastic hypoglycemia.

Veterinary pathology

57

3

432

436

10.1177/0300985820906897

https://doi.org/10.1177/0300985820906897
https://www.ncbi.nlm.nih.gov/pubmed/32148182