Academic Thesis

Basic information

Name Katayama Keiichi
Belonging department
Occupation name
researchmap researcher code B000305947
researchmap agency Okayama University of Science

Title

Reelin Receptors ApoER2 and VLDLR Are Expressed in Distinct Spatiotemporal Patterns in Developing Mouse Cerebral Cortex

Bibliography Type

 

Author

Yuki Hirota
Ken-ichiro Kubo
Kei-ichi Katayama
Takao Honda
Takahiro Fujino
Tokuo T. Yamamoto
Kazunori Nakajima

Summary

In mammalian developing brain, neuronal migration is regulated by a variety of signaling cascades, including Reelin signaling. Reelin is a glycoprotein that is mainly secreted by Cajal-Retzius neurons in the marginal zone, playing essential roles in the formation of the layered neocortex via its receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). However, the precise mechanisms by which Reelin signaling controls the neuronal migration process remain unclear. To gain insight into how Reelin signaling controls individual migrating neurons, we generated monoclonal antibodies against ApoER2 and VLDLR and examined the localization of Reelin receptors in the developing mouse cerebral cortex. Immunohistochemical analyses revealed that VLDLR is localized to the distal portion of leading processes in the marginal zone (MZ), whereas ApoER2 is mainly localized to neuronal processes and the cell membranes of multipolar cells in the multipolar cell accumulation zone (MAZ). These different expression patterns may contribute to the distinct actions of Reelin on migrating neurons during both the early and late migratory stages in the developing cerebral cortex. J. Comp. Neurol. 523:463-478, 2015. (c) 2014 Wiley Periodicals, Inc.

Magazine(name)

JOURNAL OF COMPARATIVE NEUROLOGY

Publisher

WILEY

Volume

523

Number Of Pages

3

StartingPage

463

EndingPage

478

Date of Issue

2015-02

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

ISSN

 

DOI

10.1002/cne.23691

NAID

 

PMID

 

J-GLOBAL ID

 

arXiv ID

 

ORCID Put Code

 

DBLP ID