Academic Thesis

Basic information

Name Katayama Keiichi
Belonging department
Occupation name
researchmap researcher code B000305947
researchmap agency Okayama University of Science

Title

Selective control of inhibitory synapse development by Slitrk3-PTP delta trans-synaptic interaction

Bibliography Type

 

Author

Hideto Takahashi
Kei-ichi Katayama
Kazuhiro Sohya
Hiroyuki Miyamoto
Tuhina Prasad
Yoshifumi Matsumoto
Maya Ota
Hiroki Yasuda
Tadaharu Tsumoto
Jun Aruga
Ann Marie Craig

Summary

Balanced development of excitatory and inhibitory synapses is required for normal brain function, and an imbalance in this development may underlie the pathogenesis of many neuropsychiatric disorders. Compared with the many identified trans-synaptic adhesion complexes that organize excitatory synapses, little is known about the organizers that are specific for inhibitory synapses. We found that Slit and NTRK-like family member 3 (Slitrk3) acts as a postsynaptic adhesion molecule that selectively regulates inhibitory synapse development via trans-interaction with axonal tyrosine phosphatase receptor PTP delta. When expressed in fibroblasts, Slitrk3 triggered only inhibitory presynaptic differentiation in contacting axons of co-cultured rat hippocampal neurons. Recombinant Slitrk3 preferentially localized to inhibitory postsynaptic sites. Slitrk3-deficient mice exhibited decreases in inhibitory, but not excitatory, synapse number and function in hippocampal CA1 neurons and exhibited increased seizure susceptibility and spontaneous epileptiform activity. Slitrk3 required trans-interaction with axonal PTP delta to induce inhibitory presynaptic differentiation. These results identify Slitrk3-PTP delta as an inhibitory-specific trans-synaptic organizing complex that is required for normal functional GABAergic synapse development.

Magazine(name)

NATURE NEUROSCIENCE

Publisher

NATURE PUBLISHING GROUP

Volume

15

Number Of Pages

3

StartingPage

389

EndingPage

U214

Date of Issue

2012-03

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

ISSN

 

DOI

10.1038/nn.3040

NAID

 

PMID

 

J-GLOBAL ID

 

arXiv ID

 

ORCID Put Code

 

DBLP ID