Academic Thesis

Basic information

Name Katayama Keiichi
Belonging department
Occupation name
researchmap researcher code B000305947
researchmap agency Okayama University of Science

Title

Class 5 Transmembrane Semaphorins Control Selective Mammalian Retinal Lamination and Function

Bibliography Type

 

Author

Ryota L. Matsuoka
Onanong Chivatakarn
Tudor C. Badea
Ivy S. Samuels
Hugh Cahill
Kei-ichi Katayama
Sumit R. Kumar
Fumikazu Suto
Alain Chedotal
Neal S. Peachey
Jeremy Nathans
Yutaka Yoshida
Roman J. Giger
Alex L. Kolodkin

Summary

In the vertebrate retina, neurites from distinct neuronal cell types are constrained within the plexiform layers, allowing for establishment of retinal lamination. However, the mechanisms by which retinal neurites are segregated within the inner or outer plexiform layers are not known. We find that the transmembrane semaphorins Sema5A and Sema5B constrain neurites from multiple retinal neuron subtypes within the inner plexiform layer (IPL). In Serna5A(-/-); Serna5B(-/-) mice, retinal ganglion cells (RGCs) and annacrine and bipolar cells exhibit severe defects leading to neurite mistargeting into the outer portions of the retina. These targeting abnormalities are more prominent in the outer (OFF) layers of the IPL and result in functional defects in select RGC response properties. Sema5A and Sema5B inhibit retinal neurite outgrowth through PlexinA1 and PlexinA3 receptors both in vitro and in vivo. These findings define a set of ligands and receptors required for the establishment of inner retinal lamination and function.

Magazine(name)

NEURON

Publisher

CELL PRESS

Volume

71

Number Of Pages

3

StartingPage

460

EndingPage

473

Date of Issue

2011-08

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

ISSN

 

DOI

10.1016/j.neuron.2011.06.009

NAID

 

PMID

 

J-GLOBAL ID

 

arXiv ID

 

ORCID Put Code

 

DBLP ID