Academic Thesis

Basic information

Name Katayama Keiichi
Belonging department
Occupation name
researchmap researcher code B000305947
researchmap agency Okayama University of Science

Title

Distribution of N-methyl-D-aspartate receptors (NMDARs) in the developing rat brain

Bibliography Type

 

Author

H Takai
K Katayama
K Uetsuka
H Nakayama
K Doi

Summary

The N-methyl-D-aspartate receptor (NMDAR), which is one of the glutamate receptors, is considered to have a close relationship to synaptic plasticity in the developing brain. In addition, it is known that the excessive stimulation of NMDARs can trigger neuronal apoptosis. In this study, we examined the distribution of NMDAR subunits [anti-NR1, NR2(A-C)] in the developing rat brain immunohistochemically. As a result, NR1, an essential subunit for the formation of a functional NMDAR complex, was mildly expressed ill the restricted areas such as the temporal region of the cerebral cortex and the hippocampus in the fetal brain at Embryonal Days 18 and 20. On the other hand. in neonates, NR1 was expressed widely throughout the whole brain. The distributions of NR2A and NR2C showed temporal and spatial similarities to that of NR1, while the expression of NR2B showed differences in the intensity and distribution. A progressive change in subunit expression seen prenatally and postnatally could contribute to variation of NMDARs and synaptic plasticity during the developing period. (C) 2003 Elsevier Science (USA). All rights reserved.

Magazine(name)

EXPERIMENTAL AND MOLECULAR PATHOLOGY

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE

Volume

75

Number Of Pages

1

StartingPage

89

EndingPage

94

Date of Issue

2003-08

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

ISSN

 

DOI

10.1016/S0014-4800(03)00030-3

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PMID

 

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arXiv ID

 

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DBLP ID