Academic Thesis

Basic information

Name Katayama Keiichi
Belonging department
Occupation name
researchmap researcher code B000305947
researchmap agency Okayama University of Science

Title

Effects of T-2 toxin treatment on CCl4-indueed hepatic necrosis in mice

Bibliography Type

 

Author

Yukiko Muto
Yoshiro Tani
Taro Okada
Kei-Ichi Katayama
Michio Suzuki
Koji Uetsuka
Hiroyuki Nakayama
Kunio Doi

Summary

In the present study, effects of T-2 toxin, a kind of trichothecene mycotoxins produced by the genus Fusarium, on CCl4-induced hepatic necrosis and expression of CYP2E1, a major metabolizing enzyme for CCl4, were examined in the liver of mice. T-2 toxin treatment (4 mg/kg b.w.) at one day before CCl4 inoculation (1 ml/kg b.w.) suppressed hepatic necrosis almost completely, and T-2 toxin treatment at one day after CCl4 inoculation delayed the recovery of hepatic necrosis. Although not significant, T-2 toxin (4 mg/kg b.w.) lowered the total P450 contents until 48 hrs after treatment. In addition, Western blot analysis and immunohistochemical examinations revealed that T-2 toxin significantly suppressed CYP2E1 expression from 24 to 48 hrs after treatment while it did not influence CYP3A2 expression. These results suggest that pretreatment of T-2 toxin may suppress CCl4-induced hepatic necrosis through suppression of CYP2E1 expression.

Magazine(name)

Journal of Toxicologic Pathology

Publisher

Japanese Society of Toxicologic Pathology

Volume

15

Number Of Pages

3

StartingPage

161

EndingPage

166

Date of Issue

2002

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

ISSN

 

DOI

10.1293/tox.15.161

NAID

 

PMID

 

J-GLOBAL ID

 

arXiv ID

 

ORCID Put Code

 

DBLP ID