Competitive research funds

Basic information

Name Tsunedomi　Ryouichi
Belonging department
Occupation name
researchmap researcher code 1000361639
researchmap agency Okayama University of Science

Title 

Identification of the HSP70 peptide for the development of cancer immunetherapy

					

					

						

							

								

									
Provider 

									
								

							

						

						
Japan Society for the Promotion of Science

					

					

						

							

								

									
System 

									
								

							

						

						
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research

					

					

						

							

								

									
From Date 

									
								

							

						

						
2014-04

					

					

						

							

								

									
To Date 

									
								

							

						

						
2016-03

					

					

						

							

								

									
OwnerRole 

									
								

							

						

						
 

					

					

						

							

								

									
Author 

									
								

							

						

						
OKA Masaaki
YOSHIMURA Kiyoshi
TSUNEDOMI Ryouichi

					

					

						

							

								

									
Category 

									
								

							

						

						
Grant-in-Aid for Challenging Exploratory Research

					

					

						

							

								

									
Summary 

									
								

							

						

						
We identified the Heat Shock Protein (HSP) 70 as a specific antigen of hepatocellular carcinoma. Furthermore, the phase I study of HSP70-mRNA introduced dendritic cells therapy showed the safety and efficacy. In this study, we tried to identify the HSP70 peptide sequence, which can induce the anti-tumor response, in order to the development of useful peptide vaccine therapy for cancer. Candidate HSP70 peptides predicted as multi-HLA binding potency were confirmed by ELISpot assay and ELISA for IFN-gamma production. The safty of the peptides were examined in rats and dogs. We started a clinical trial of first in Human HSP70 peptide immunetherapy for several cancers.