CD4 and FOXP3 as predictive markers for the recurrence of T3/T4a stage II colorectal cancer: applying a novel discrete Bayes decision rule

Yuki Nakagami
Shoichi Hazama
Nobuaki Suzuki
Shin Yoshida
Shinobu Tomochika
Hiroto Matsui
Yoshitaro Shindo
Yukio Tokumitsu
Satoshi Matsukuma
Yusaku Watanabe
Michihisa Iida
Ryouichi Tsunedomi
Shigeru Takeda
Tomonobu Fujita
Yutaka Kawakami
Hiroyuki Ogihara
Yoshihiko Hamamoto
Tatsuya Ioka
Tsuyoshi Tanabe
Tomio Ueno
Hiroaki Nagano

Abstract

 Background

 We recently reported the relapse-free survival (RFS) significance of the combination of CD4+ and forkhead box P3+ (FOXP3) T-cell densities identified by immunohistochemistry in patients with stage I, II, and III colorectal cancer (CRC) who underwent curative resections. This study was designed to determine the optimal combination of markers that predict recurrence in patients with T factors of T3/T4a stage II CRC by applying a novel Bayes decision rule.

 Methods

 Using 137 cancer tissue specimens from T3/T4a stage II patients, 12 clinicopathologic and immune factors were analysed as predictive candidates for recurrence.

 Results

 Our study showed that the combination of low CD4+ and low FOXP3+ T-cell densities resulted in extremely poor RFS.

 Conclusions

 Adjuvant chemotherapy may be considered for patients with a combination of low CD4+ and low FOXP3+ T-cell densities. The discovery of this new prognostic indicator is important for the appropriate management of patients undergoing curative resection for T3/T4a stage II CRC.

BMC Cancer

Springer Science and Business Media LLC

22

1

1071

1071

10.1186/s12885-022-10181-7

https://doi.org/10.1186/s12885-022-10181-7
https://link.springer.com/content/pdf/10.1186/s12885-022-10181-7.pdf
https://link.springer.com/article/10.1186/s12885-022-10181-7/fulltext.html