Multiple DNA repair pathways are involved synergistically in the protection against DNA alkylation damage in fission yeast

K. Kanamitsu, S. Inatani, S. Ikeda

2010 International Chemical Congress of Pacific Basin Societies

米国ハワイ州ホノルル

Endogenous and environmental alkylating agents generate cytotoxic and mutagenic methylated bases in DNA. Previously, we showed that the abundant toxic lesion 3-methyladenine is excised by two specific DNA glycosylases, Mag1p and Mag2p, which initiate the