New Sesquiterpene Lactone Dimer, Uvedafolin, Extracted from Eight Yacon Leaf Varieties (Smallanthus sonchifolius): Cytotoxicity in HeLa, HL-60, and Murine B16-F10 Melanoma Cell Lines

Yurika Kitai, Kana Hayashi, Moe Otsuka, Hisashi Nishiwaki, Tatsuya Senoo, Tomohiko Ishii, Genta Sakane, Makoto Sugiura, and Hirotoshi Tamura

Uvedafolin
Uvedafolin, 1, a new sesquiterpene lactone dimer, isolated from the leaves of Smallanthus sonchifolius with five related compounds, 2-6, and their cytotoxicity was assessed against three tumor cell lines (HeLa, HL-60, B16-F10 melanoma). The stereostructure of 1 was newly elucidated by ESI-TOF-MS, 1D/2D NMR and single-crystal X-ray diffraction. Dimers, 1 and 2, had the most effective IC50 values 0.2-1.9 μM against the three tumor cell lines when compared with monomers, 3-6, (IC50 values 0.7-9.9 μM) and etoposide (IC50 values 0.8-114 μM). The ester linkages of two sets of monomers, uvedalin, 5, and sonchifolin, 6, for 1, and enhydrin, 4, and sonchifolin, 6, for 2, as well as the acetyl group at the C-9 position, were essential for the high cytotoxicity. The dimers, 1 and 2, would have potential as anticancer agents.

https://doi.org/10.1021/acs.jafc.5b05229

New Sesquiterpene Lactone Dimer, Uvedafolin, Extracted from Eight Yacon Leaf Varieties (Smallanthus sonchifolius): Cytotoxicity in HeLa, HL-60, and Murine B16-F10 Melanoma Cell Lines

Journal of Agricultural and Food Chemistry

American Chemical Society

63

50

10856

10861