Culcitiolides A-D, four new eremophilane-type sesquiterpene derivs. from Senecio culcitioides

Nozaki, Hiroshi; Hayashi, Ken-ichiro; Kawai, Mikiko; Mitsui, Taichi; Kido, Masahiro; Tani, Hiroyuki; Takaoka, Daisuke; Uno, Hidemitsu; Ohira, Susumu; Kuboki, Atsuto; Matsuura, Nobuyasu

Four new eremophilane-type sesquiterpenes, culcitiolides A-D, were isolated from the stem of Senecio culcitioides Sch. Bip (Asteraceae). Their structures were established by detailed 2D NMR spectroscopic and single-crystal X-ray experiments. These compounds were assessed for inhibitory activity against nuclear factor kappaB (NF-kappaB). Culcitiolides C and D at 20 microM showed 97 and 100% inhibition of NF-kappaB activity, respectively.                                                                                                                                                               
            

Natural Product Communications

Sage Journals

7

4

427

430