Stereocontrolled synthesis of (_)-methyl 3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate, a major metabolite of Caribbean sponge, Plakortis halichondrioides, using reactions of alkylidenecarbenes in one pot.

Akiyama, Megumi; Isoda, Yuichi; Nishimoto, Masato; Kobayashi, Aki; Togawa, Daisuke; Hirao, Nobuaki; Kuboki, Atsuhito; Ohira, Susumu.

synthesis, natural product, alkylidenecarbenes

Tetrahedron Letters

Elsevier

46

44

7483

7485