Synthesis and structure of diastereomers of pentenocin B produced by Trichoderma hamatum FO-6903.

Ohira, Susumu; Fujiwara, Hiroyuki; Maeda, Kiyomi; Habara, Masaharu; Sakaedani, Naomi; Akiyama, Megumi; Kuboki, Atsuhito.

All diastereomers of pentenocin B, an inhibitor of interleukin-1β converting enzyme produced by Trichoderma hamatum FO-6903, were synthesized in chiral forms starting from L-threonine. Absolute configurations of natural pentenocin B were clarified to be 4S, 5R, and 6R.

Tetrahedron Letters

Elsevier Science B.V.

45

8

1639

1641