Conference

Basic information

Name Katayama Seiichi
Belonging department
Occupation name
researchmap researcher code 1000052332
researchmap agency Okayama University of Science

Title 

Structure-based functional prediction of a hypothetical Clostridium perfringens carboxypeptidase

					

					

						

							

								

									
Author 

									
								

							

						

						
Nozomu Matsunaga, Anri Miyoshi, Yasuo Hitsumoto, Seiichi Katayama

					

					

						

							

								

									
Journal 

									
								

							

						

						
The 99th Annual Meeting of Japanese Societyfor Bacteriology

					

					

						

							

								

									
Publication Date 

									
								

							

						

						
2026/03/21

					

					

						

							

								

									
Invited 

									
								

							

						

						
Not exist

					

					

						

							

								

									
Language 

									
								

							

						

						
Japanese

					

					

						

							

								

									
  

									
								

							

						

						
学会講演(シンポジウム・セミナー含む)

					

					

						

							

								

									
Conference Class 

									
								

							

						

						
Domestic conferences

					

					

						

							

								

									
Conference Type 

									
								

							

						

						
Poster sessions

					

					

						

							

								

									
Promoter 

									
								

							

						

						
Japanese Societyfor Bacteriology

					

					

						

							

								

									
Venue 

									
								

							

						

						
Hiroshima City, Japan

					

					
					

						

							

								

									
Summary 

									
								

							

						

						
Clostridium perfringens, a strictly anaerobic spore-forming bacterium, is a pathogenic bacterium that causes gas gangrene and food poisoning in humans. We found that human fibronectin (Fn), one of such extracellular matrix proteins, binds to C. perfringens cells, and exhibits several fibronectin-binding proteins (Fbps) [FbpA (CPE0737), FbpB (CPE0847), FbpC (CPE0625), and FbpD (CPE0630)] in C. perfringens. These Fbps are all hypothetical proteins. In this study, we focused on FbpC (CPE0625). FbpC were predicted physiochemical characterization and functional using several server. Analyses using ExPAsy and GO term predictions via D-I-TASSER suggest that FbpC is one of a cell-wall binding protein. The results of these prediction supported our previous reports. FbpC was identified as a potential carboxypeptidase through feature-based annotation (NCBI-CD, Prosite, and InterPro), similarity-based annotation (BLASTp), and structure-similarity-based annotation (DALI and Foldseek). Moreover, it was revealed that FbpC possessed carboxypeptidase activity. In conclusion, FbpC is carboxypeptidase associated with cell wall.