The conventionally used plasticizer di-2-ethy1hexy1phthalate (DEHP), used for polyvinyl chloride, for the manufacturing of blood circulation tubes was found to be associated with a risk for testicular toxicity. Thus, the development of blood circulation tubes by using other plasticizers such as trioctyl trimellite (TOTM) or Di-isononyl-cyclohexane-1, 2-dicarboxylate (DINCH) that is not associated with a risk for testicular toxicity has recently been under way. However, biocompatibilities such as blood compatibility of these plasticizers against human blood are not well known. In the present study, the activated coagulation time (ACT) and the hemolysis ratio of the blood samples added 3 types of plasticizers were measured to evaluate the blood compatibility of these plasticizers. The results showed negligible effects of each plasticizer on blood coagulation and hemolysis.
Research papers (publications of university or research institution)
