Significance of tumor-infiltrating immune cells in spontaneous canine mammary gland tumor: 140 cases.

[Kohei Saeki,Yoshifumi Endo,Kazuyuki Uchida,Ryohei Nishimura,Nobuo Sasaki,Takayuki Nakagawa]

The numbers of tumor infiltrating T lymphocytes, B lymphocytes and antigen presenting cells were evaluated in an immunohistochemical manner in 140 canine spontaneous mammary gland tumor (MGT) tissues. As a result, we found a statistically significant increase in the number of intratumoral T lymphocytes (23.2 ± 23.8) in the malignant MGT group (n=51) compared with the benign MGT group (14.0 ± 16.0, n=89; P<0.05). Moreover, the high T lymphocyte infiltration in the malignant group correlated with poor prognosis in multivariate analysis (P<0.05). This study indicated the relationship between increased infiltrating T lymphocytes and canine MGT malignancy.

The Journal of veterinary medical science

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