To investigate the possibility of procalcitonin as a prognostic index of SIRS and a target for blood purification therapy in dogs, a measuring system for canine procalcitonin using ELISA has been established. A recombinant canine procalcitonin protein and polyclonal antibodies were obtained by cloning canine procalcitonin gene cDNA. These antibodies specifically recognized canine procalcitonin and was able to detect canine procalcitonin by ELISA.