Canine IgA nephropathy: a case report

Akira Yabuki
Takako Shimokawa Miyama
Moeko Kohyama
Osamu Yamato

Immunoglobulin (Ig) A nephropathy is a rare form of canine glomerular disease. This report describes a case of canine IgA nephropathy showing characteristics typical of human IgA nephropathy. An 8-year-old, spayed female Miniature Dachshund showed persistent severe proteinuria without azotemia. She was receiving long-term glucocorticoid therapy due to chronic gastritis and an intra-abdominal suture granuloma. A renal biopsy demonstrated mesangial proliferative glomerulonephritis with predominantly mesangial IgA deposition and electron-dense deposits in the paramesangium. These findings closely resembled those of human IgA nephropathy. Glucocorticoid treatment was discontinued, and the angiotensin-converting enzyme inhibitor enalapril was administrated as an antiproteinuric agent. The proteinuria subsequently went into remission, and the patient has maintained good condition without recurrence.

JOURNAL OF VETERINARY MEDICAL SCIENCE

JAPAN SOC VET SCI

78

3

513

515

10.1292/jvms.15-0161

https://doi.org/10.1292/jvms.15-0161
https://www.ncbi.nlm.nih.gov/pubmed/26596464
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829528
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