Academic Thesis

Basic information

Name Shimizu Yuki
Belonging department
Occupation name
researchmap researcher code R000000424
researchmap agency Okayama University of Science

Title

Distal renal tubular acidosis and lethargy associated with zonisamide treatment in a dog with idiopathic epilepsy

Bibliography Type

Author

Takamasa Itoi, Natsuki Akashi, Yuki Shimizu, Keisuke Sugimoto, Akihisa Hata, Kenji Kutara, Takako Shimokawa Miyama, Teppei Kanda

Summary

Abstract A 3‐year‐old neutered male golden retriever administered zonisamide for the treatment of seizures showed lethargy and had normal anion gap metabolic acidosis with hypokalaemia, hyperchloremia, and alkaline urine. The serum zonisamide concentration was close to the upper limit, which raised a suspicion of adverse effects of zonisamide. This is the first report showing that the fractional excretion of bicarbonate after compensation for the plasma bicarbonate concentration by a sodium bicarbonate infusion was approximately 5%, indicating distal renal tubular acidosis (RTA). The serum zonisamide concentration decreased, and adverse effects were abated by reducing the zonisamide dosage. Diagnostic therapy with bicarbonate served as a means of compensating for bicarbonate deficiency and contributed to the clinical diagnosis of the condition in zonisamide‐associated RTA in dogs.

Magazine(name)

veterinary medicine and science

Publisher

Wiley

Volume

8

Number Of Pages

6

StartingPage

2256

EndingPage

2260

Date of Issue

2022/08

Referee

Exist

Invited

Not exist

Language

English

Thesis Type

Research papers (academic journals)

ISSN

DOI

10.1002/vms3.905

NAID

PMID

J-GLOBAL ID

arXiv ID

ORCID Put Code

DBLP ID