Association between Vitamin Intake and Chronic Kidney Disease According to a Variant Located Upstream of the PTGS1 Gene: A Cross-Sectional Analysis of Shika Study

Kim-Oanh Pham  1   2 , Akinori Hara  2 , Hiromasa Tsujiguchi  2 , Keita Suzuki  2 , Fumihiko Suzuki  2   3 , Sakae Miyagi  4 , Takayuki Kannon  5 , Takehiro Sato  5 , Kazuyoshi Hosomichi  5 , Hirohito Tsuboi  6 , Thao Thi Thu Nguyen  7 , Yukari Shimizu  8 , Yasuhiro Kambayashi  9 , Masaharu Nakamura  2 , Chie Takazawa  2 , Haruki Nakamura  2 , Toshio Hamagishi  2 , Aki Shibata  2 , Tadashi Konoshita  10 , Atsushi Tajima  5 , Hiroyuki Nakamura  2

Chronic kidney disease (CKD) patients have been advised to take vitamins; however, the effects have been controversial. The individual differences in developing CKD might involve genetic variants of inflammation, including variant rs883484 located upstream of the prostaglandin-endoperoxide synthase 1 (PTGS1) gene. We aimed to identify whether the 12 dietary vitamin intake interacts with genotypes of the rs883484 on developing CKD. The population-based, cross-sectional study had 684 Japanese participants (≥40 years old). The study used a validated, brief, self-administered diet history questionnaire to estimate the intake of the dietary vitamins. CKD was defined as estimated glomerular filtration < 60 mL/min/1.73 m2. The study participants had an average age of 62.1 ± 10.8 years with 15.4% minor homozygotes of rs883484, and 114 subjects had CKD. In the fully adjusted model, the higher intake of vitamins, namely niacin (odds ratio (OR) = 0.74, 95% confidence interval (CI): 0.57−0.96, p = 0.024), α-tocopherol (OR = 0.49, 95% CI: 0.26−0.95, p = 0.034), and vitamin C (OR = 0.97, 95% CI: 0.95−1.00, p = 0.037), was independently associated with lower CKD tendency in the minor homozygotes of rs883484. The results suggested the importance of dietary vitamin intake in the prevention of CKD in middle-aged to older-aged Japanese with minor homozygous of rs883484 gene variant.
Keywords: PTGS1; chronic kidney disease; eGFR; nutritional vitamins; precision nutrition.

Nutrients

14

10

2082