Effect of 2% meloxicam injection in Holstein dairy cows on acute clinical mastitis without systemic symptoms

Keiichi HISAEDA ,  Masakatsu NOHARA ,  Naomi OHTA ,  Akira GOTO ,  Yoichi INOUE ,  Akihisa HATA ,  Yasunori SHINOZUKA

This study aimed the efficacy of meloxicam(MX) in treating acute clinical mastitis
(ACM) without systemic symptoms in Holstein cows by studying improvement in
udder pain, changes in prostaglandin E2（PGE2） and bradykinin (BK) levels in the
milk, and milk yield (MY) after healing. Forty-two cows with ACM were randomly
assigned to the MX treatment group (T group; n=21) and the control group (C group;
n=21). At onset of illness (day 0) , the T group received a 0.5 mg/kg subcutaneous
(SC) injection of MX whereas the C group received 15 ml SC of saline solution as a
placebo. Udder tenderness (UT) was measured, and milk samples were collected on
days 0-3. There was little change in the MY of the T group before and after healing,
whereas MY in the C group was significantly lower than after healing. UT on day 3
in the T group was significantly lower than that in the C group. PGE2 levels
significantly decreased from day 0 to day 3 in both groups. A significant negative
correlation between PGE2 and linear score was observed on day 1 in the T group, but
not in the C group. In ACM without systemic symptoms, the administration MX may
be useful for restoring MY and reducing udder pain after healing.

Journal of Veterinary Medical Science

86

4

374

380

10.1292/jvms.23-0424