論文

基本情報

氏名 兒玉 朋子
氏名(カナ) コダマ トモコ
氏名(英語) Kodama Tomoko
所属 獣医学部 獣医学科
職名 助教
researchmap研究者コード R000034570
researchmap機関 岡山理科大学

題名

A selective eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood glucose in Zucker fatty diabetes mellitus rat

単著・共著の別

共著

著者

Ko Adachi, Tomoko Kodama, Kosuke Otani, Keito Sano, Asuka Sugiyama, Muneyoshi Okada, Hideyuki Yamawaki

概要

Eukaryotic elongation factor 2 kinase (eEF2K) is a protein kinase, regulating peptide translation. Zucker fatty diabetes mellitus (ZFDM) rat is a recently developed obesity and type 2 diabetes animal model with a missense mutation (fa) in leptin receptor gene (Lepr). ZFDM-Leprfa/fa rats (Homo) develop obesity and type 2 diabetes, while ZFDM-Leprfa/+ rats (Hetero) are normal. The aim of this study was to determine effects of A484954 on glucose metabolism in ZFDM rats. A484954 (2.5 mg/kg) or carboxymethyl cellulose (CMC; 0.5 %), a vehicle was injected intraperitoneally for 15 days in 17-19-week-old rats. Compared with Hetero CMC, in Homo CMC; 1) blood and urine glucose levels were significantly elevated, 2) Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was significantly elevated, 3) mRNA expression of sodium-glucose cotransporter (SGLT)2 in kidney tended to be elevated, while that of glucose transporter (GLUT)4 in vastus lateralis muscle decreased. Compared with Homo CMC, in Homo A484954; 1) blood glucose was significantly reduced, while urine glucose did not change, 2) HOMA-IR tended to decrease, 3) mRNA expression of SGLT2 in the kidney and GLUT4 in the muscle did not change. This study demonstrates for the first time that A484954 induces hypoglycemic effects in Homo partly via preventing insulin resistance.

発表雑誌等の名称

Journal of Pharmacogical Sciences

出版者

158

3

開始ページ

270

終了ページ

275

発行又は発表の年月

2025/06

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

10.1016/j.jphs.2025.05.006

ID:NAID(CiNiiのID)

ID:PMID

40436488

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID