論文

基本情報

氏名 兒玉 朋子
氏名(カナ) コダマ トモコ
氏名(英語) Kodama Tomoko
所属 獣医学部 獣医学科
職名 助教
researchmap研究者コード R000034570
researchmap機関 岡山理科大学

題名

Effects of a Soluble Guanylate Cyclase Stimulator Riociguat on Contractility of Isolated Pulmonary Artery and Hemodynamics of U46619-Induced Pulmonary Hypertension in Dogs

単著・共著の別

著者

Satoshi Kameshima, Yuki Nakamura, Kenji Uehara, Tomoko Kodama, Hideyuki Yamawaki, Kotaro Nishi, Shozo Okano, Ryo Niijima, Yuya Kimura, Naoyuki Itoh

概要

Soluble guanylate cyclase (sGC) stimulator riociguat is a relatively novel therapeutic agent for pulmonary hypertension (PH) in human medicine. Riociguat induces endothelium-independent pulmonary artery (PA) relaxation by directly activating the sGC-cyclic guanosine-3′,5′-monophosphate (cGMP) pathway in muscle cells. Although riociguat may be effective in the treatment of dogs with refractory PH, basic studies on its clinical application in veterinary medicine are lacking. The present study aimed to explore the effects of riociguat on the contractility of an isolated canine PA and the hemodynamics of dogs with acute PH. In an isolated endothelium-denuded canine PA, the effects of riociguat on endothelin (ET)-1-induced contraction and cGMP levels were investigated using the Magnus method and ELISA, respectively. The effect of riociguat on the hemodynamics of the thromboxane A2 analog U46619-induced PH model dog was examined by invasive catheterization. Riociguat increased cGMP levels and reduced ET-1-induced contraction of the isolated PA. Riociguat inhibited the U46619-induced elevation of PA pressure and pulmonary vascular resistance and increased cardiac output, but it had no effect on basal systemic blood pressure. These results demonstrate for the first time that riociguat can inhibit the elevation of PA pressure through PA relaxation via an endothelium-independent increase in cGMP in dogs with PH.

発表雑誌等の名称

Veterinary Sciences

出版者

MDPI AG

10

2

開始ページ

159

終了ページ

159

発行又は発表の年月

2023/02

査読の有無

有り

招待の有無

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

10.3390/vetsci10020159

ID:NAID(CiNiiのID)

ID:PMID

36851463

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID