論文

基本情報

氏名 児島 一州
氏名(カナ) コジマ イッシュウ
氏名(英語) Kojima Isshu
所属 獣医学部 獣医学科
職名 助教
researchmap研究者コード R000055330
researchmap機関 岡山理科大学

題名

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

単著・共著の別

共著

著者

Shuhei Tsujino/Sayaka Deguchi/Tomo Nomai/Miguel Padilla-Blanco/Arnon Plianchaisuk/Lei Wang/Mst Monira Begum/Keiya Uriu/Keita Mizuma/Naganori Nao/Isshu Kojima/Tomoya Tsubo/Jingshu Li/Yasufumi Matsumura/Miki Nagao/Yoshitaka Oda/Masumi Tsuda/Yuki Anraku/Shunsuke Kita/Hisano Yajima/Kaori Sasaki-Tabata/Ziyi Guo/Alfredo A Hinay Jr/Kumiko Yoshimatsu/Yuki Yamamoto/Tetsuharu Nagamoto/Hiroyuki Asakura/Mami Nagashima/Kenji Sadamasu/Kazuhisa Yoshimura/Hesham Nasser/Michael Jonathan/Olivia Putri/Yoonjin Kim/Luo Chen/Rigel Suzuki/Tomokazu Tamura/Katsumi Maenaka/Takashi Irie/Keita Matsuno/Shinya Tanaka/Jumpei Ito/Terumasa Ikeda/Kazuo Takayama/Jiri Zahradnik/Takao Hashiguchi/Takasuke Fukuhara/Kei Sato; Genotype to Phenotype Japan (G2P‐Japan) Consortium

概要

In middle to late 2023, a sublineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB, EG.5.1 (a progeny of XBB.1.9.2), is spreading rapidly around the world. We performed multiscale investigations, including phylogenetic analysis, epidemic dynamics modeling, infection experiments using pseudoviruses, clinical isolates, and recombinant viruses in cell cultures and experimental animals, and the use of human sera and antiviral compounds, to reveal the virological features of the newly emerging EG.5.1 variant. Our phylogenetic analysis and epidemic dynamics modeling suggested that two hallmark substitutions of EG.5.1, S:F456L and ORF9b:I5T are critical to its increased viral fitness. Experimental investigations on the growth kinetics, sensitivity to clinically available antivirals, fusogenicity, and pathogenicity of EG.5.1 suggested that the virological features of EG.5.1 are comparable to those of XBB.1.5. However, cryo-electron microscopy revealed structural differences between the spike proteins of EG.5.1 and XBB.1.5. We further assessed the impact of ORF9b:I5T on viral features, but it was almost negligible in our experimental setup. Our multiscale investigations provide knowledge for understanding the evolutionary traits of newly emerging pathogenic viruses, including EG.5.1, in the human population.

発表雑誌等の名称

Microbiology and immunology

出版者

68

9

開始ページ

305

終了ページ

330

発行又は発表の年月

2024/09

査読の有無

有り

招待の有無

記述言語

英語

掲載種別

ISSN

ID:DOI

10.1111/1348-0421.13165.

ID:NAID(CiNiiのID)

ID:PMID

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID