論文

基本情報

氏名 児島 一州
氏名(カナ) コジマ イッシュウ
氏名(英語) Kojima Isshu
所属 獣医学部 獣医学科
職名 助教
researchmap研究者コード R000055330
researchmap機関 岡山理科大学

題名

The First Isolation and Characterization of Bat Jeilongviruses in Japan. 

単著・共著の別

共著

著者

Sata S, Kojima I, Esaki M, Funakoshi K, Kajihara M, Hirano S, Murakami S, Miyazaki K, Ozawa M, Okuya K.

概要

Bats represent natural reservoirs of several paramyxoviruses, raising concerns about the potential for these viruses to cause cross-species infections. In this study, we isolated two jeilongviruses belonging to the family Paramyxoviridae from oral swab samples of the Eastern bent-wing bat (Miniopterus fuliginosus) and Far Eastern myotis bat (Myotis bombinus) in Kagoshima Prefecture, Japan. Notably, this is the first report isolating bat paramyxoviruses in Japan. Genomic analyses revealed a high identity between Kagoshima isolates (PMV/Bat35 and PMV/Bat111) and jeilongvirus B16-40, previously isolated from a Schreiber's bent-wing bat (Miniopterus schreibersii) in South Korea in 2016. PMV/Bat35 infected and replicated in a range of cell lines derived from different animal species, although the level of syncytium formation varied among cell lines. Animal experiments revealed that Syrian hamsters inoculated intranasally with PMV/Bat35 did not exhibit clinical symptoms or significant weight loss. Nevertheless, viral genes were detected in the lungs and tracheas of Syrian hamsters on 2- and 5-day postinfection (dpi). Importantly, neutralizing antibodies against PMV/Bat35 developed in hamsters on 14 dpi. These results suggest that bat jeilongviruses can cross the species barriers. Our findings highlight the critical importance of ongoing monitoring and characterization of viruses circulating in bat populations to assess the risk of zoonotic outbreaks. 

発表雑誌等の名称

Transbound Emerg Dis.

出版者

2024

5530007

開始ページ

9

終了ページ

発行又は発表の年月

2024/12

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

10.1155/tbed/5530007.

ID:NAID(CiNiiのID)

ID:PMID

40303027

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID