論文

基本情報

氏名 東 恒仁
氏名(カナ) ヒガシ ツネヒト
氏名(英語) Higashi Tsunehito
所属 獣医学部 獣医学科
職名 准教授
researchmap研究者コード 5000085325
researchmap機関 岡山理科大学

題名

Histone H2A mobility is regulated by its tails and acetylation of core histone tails

単著・共著の別

 

著者

Tsunehito Higashi
Sachihiro Matsunaga
Keisuke Isobe
Akihiro Morimoto
Tomoko Shimada
Shogo Kataoka
Wataru Watanabe
Susumu Uchiyama
Kazuyoshi Itoh
Kiichi Fukui

概要

Historic tail domains play important roles in cellular processes, such as replication, transcription, and chromosome condensation. Histone H2A has one central and two tail domains, and their functions have mainly been studied from a biochemical perspective. In addition, analyses based on visualization have been employed for functional analysis of some chromatin proteins. In this study, we analyzed histone H2A mobility in vivo by two-photon FRAP, and elucidated that the histone H2A N- and C-terminal tails regulate its mobility. We found that histone H2A mobility was increased following treatment of host cells with a histone deacetylase inhibitor. Our results support a model in which core histone tails directly regulate transcription by interacting with nucleosome DNA via electrostatic interactions. (c) 2007 Published by Elsevier Inc.

発表雑誌等の名称

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

出版者

ACADEMIC PRESS INC ELSEVIER SCIENCE

357

3

開始ページ

627

終了ページ

632

発行又は発表の年月

2007-06

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

 

ID:DOI

10.1016/j.bbrc.2007.03.203

ID:NAID(CiNiiのID)

 

ID:PMID

 

JGlobalID

 

arXiv ID

 

ORCIDのPut Code

 

DBLP ID