Endothelial dysfunction accelerates AKI-to-CKD transition by promoting β-catenin activation in macrophages

Masanobu Takasu, Seiji Kishi, Hajime Nagasu, Megumi Kondo, Masafumi Wada, Rie Tatsugawa, Eriko Kajimoto, Akira Hirano, Tsukasa Iwakura, Yoshihisa Wada, Hiroyuki Kadoya, Kengo Kidokoro, Masanori Iseki, Tamaki Sasaki, Yashpal S Kanwar, Naoki Kashihara

Our study provides novel insights into the mechanisms underlying the transition from acute kidney injury (AKI) to chronic kidney disease (CKD), with a focus on the role of endothelial nitric oxide synthase (eNOS). We believe our findings, particularly their potential implications for developing new therapeutic strategies to prevent CKD progression, will be of significant interest to your readership and could significantly improve patient care.

American Journal of Physiology-Renal Physiology

American Physiological Society

330

1

F89

F101

10.1152/ajprenal.00212.2025

https://doi.org/10.1152/ajprenal.00212.2025