論文

基本情報

氏名 池田 正五
氏名(カナ) イケダ シヨウゴ
氏名(英語) Ikeda Shiyogo
所属 生命科学部 生物科学科
職名 教授
researchmap研究者コード 1000113908
researchmap機関 岡山理科大学

題名

Alterations of retinoblastoma susceptible gene accompanied by c-myc amplification in human bone and soft tissue tumors.

単著・共著の別

著者

Ozaki T, Ikeda S, Kawai A, Inoue H, Oda T.

概要

The present study was undertaken to examine oncogene abnormalities in human bone and soft tissue tumors. Twenty four tumor tissues and one human cell strain established from an osteosarcoma were examined by Southern blot analysis using a recessive oncogene (p0.9R and p3.8R derived from a cDNA of the Rb gene) and eight dominant oncogenes (c-myc, c-K-ras, c-fos, c-raf-1, c-fms, c-sis, N-myc, and c-erb B) as probes. Homozygous deletions or other alterations within the Rb locus were found in 3 of 6 osteosarcomas, 1 osteosarcoma cell line, 1 of 3 malignant fibrous histiocytomas and 1 of 2 Ewing's sarcomas. On the other hand, amplification of c-myc was found in 2 osteosarcomas and 1 osteosarcoma cell line. All cases with c-myc amplification had alterations in the structure of the Rb locus, and these patients showed rapid clinical malignancy progression and a probable tendency to bone metastases. Results of this study suggest that structural alterations of the Rb gene and amplification of c-myc might play an important role in the clinical course and pathogenesis of osteosarcoma.


発表雑誌等の名称

Cellular and Molecular Biology

出版者

39

開始ページ

235

終了ページ

242

発行又は発表の年月

1993/03

査読の有無

有り

招待の有無

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID