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| 基本情報 |
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| 氏名 |
窪木 厚人 |
| 氏名（カナ） |
ｸﾎﾞｷ ｱﾂﾋﾄ |
| 氏名（英語） |
Kuboki Atsuhito |
| 所属 |
生命科学部 生物科学科 |
| 職名 |
准教授 |
| researchmap研究者コード |
1000311530 |
| researchmap機関 |
岡山理科大学 |
New chalcone dimers from Caesalpinia ferrea Mart act as potent inhibitors of DNA topoisomerase II
S. Ohira, K. Takaya, T. Mitsui, M. Kido, M. Kakumoto, K. Hayashi, K. Hayashi, A. Kuboki, H. Tani, S. Ikeda, M. Iinuma, M. Akao, H. Nozaki
New chalcone dimers, pauferrol B (I), and pauferrol C (II), were isolated from the stems of Caesalpinia ferrea Mart, and their structures were determined on the basis of 2D NMR spectroscopy. These new chalcone dimers showed potent inhibitory activities against human topoisomerase II and cell proliferation via the induction of apoptosis in human leukemia HL 60 cells. Absolute configurations of 2 and 3 were estimated by the comparison of CD spectra with a dihydrobenzofuran derivative 4, which was enantioselectively synthesized from 2-hydroxyphenyl acetic acid.
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