Resveratrol Oligosaccharides (Gluco-Oligosaccharides) Effectively Inhibit SARS-CoV- 2 Infection: Glycoside (Polysaccharide) Approach for Treatment of COVID-19

Hiroki Hamada, Hatsuyuki Hamada, Kei Shimoda, Atsuhito Kuboki, Takafumi Iwaki, Yuya Kiriake, and Kohji Ishihara

To examine the anti-SARS-CoV-2 effects of resveratrol oligosaccharides, human MRC5 lung cells, which had been infected with SARS-CoV-2, were incubated with different concentrations of resveratrol oligosaccharides. These suppressed the cell death induced by SARS-CoV-2 infection, more efficiently, at 0.1% concentration, than resveratrol itself. Resveratrol oligosaccharides effectively inhibited SARS-CoV-2 infection in the 5% to 10% concentration range, which indicates that these compounds could be useful anti-SARS-CoV-2 agents.

Natural Product Communications

Sage Journals

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