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| 基本情報 |
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| 氏名 |
窪木 厚人 |
| 氏名（カナ） |
ｸﾎﾞｷ ｱﾂﾋﾄ |
| 氏名（英語） |
Kuboki Atsuhito |
| 所属 |
生命科学部 生物科学科 |
| 職名 |
准教授 |
| researchmap研究者コード |
1000311530 |
| researchmap機関 |
岡山理科大学 |
Total synthesis of ( ±)-nitidanin and novel procedures for determination of the location of the side chains on 1,4-benzodioxane.
Kuboki, Atsuhito; Yamamoto, Toru; Taira, Mamie; Arishige, Tetsuya; Ohira, Susumu.
Regioselective cycloaddition of 5-[1,1-(ethylenedioxy)ethyl]-3-methoxy-1,2-benzoquinone and silyl-protected sinapyl alc. gave 1,4-benzodioxane (±)-I [R = SiMe2CMe3, R1 = 1-methyldioxolan-1-yl (II)], which was converted to the antimalarial (±)-nitidanin I (R = H, R1 = E-CH:CHCH2OH). Two novel procedures were developed to determine the location of the side chains of the adduct II based on partial ring cleavage.
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