Enzymatic Synthesis of Memantine (Memary) Oligosaccharides (Gluco-oligosaccharides) and their application as anti-dementia drugs that cross the Blood-Brain Barrier (BBB)

H. Hamada, K. Ishihara, K. Shimoda, A. Kuboki, Y. Kiriake, R. Hosoda

Memantine (memary) oligosaccharides (gluco-oligosaccharides) were synthesized by enzymatic glycosylation, using cyclodextrin glucanotransferase as a biocatalyst. Although memantine hardly crosses the blood–brain barrier (BBB) in the mouse brain,  memantine  oligosaccharides  crossed  the  BBB  of  mouse  brain  and  were incorporated  into  the mouse  brain  tissue.  Our  investigations  indicated  that memantine  modified  with  oligosaccharides  might  have  gained  a  BBB-crossing ability. Furthermore, during the Y-maze test using senescence-accelerated mouse prone 8, our study revealed that the time spent in the novel Y-maze arm by the memantine-oligosaccharides-treated mouse was longer than that spent in the novel arm by the memantine-treated-mouse. Therefore, this study established that since memantine  oligosaccharides  could  penetrate  the  BBB  of  mouse  brain  and  be incorporated into the mouse’s brain tissue, they could also enhance spatial learning.

Int. J. Curr. Microbiol. App. Sic.

12

08

1

6

2319-7706

10.20546/ijcmas.2023.1208.001