論文

基本情報

氏名 安藤 秀哉
氏名(カナ) アンドウ ヒデヤ
氏名(英語) Ando Hideya
所属 生命科学部 生物科学科
職名 教授
researchmap研究者コード
researchmap機関

題名

Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins.

単著・共著の別

共著

著者

Wagatsuma T, Suzuki E, Shiotsu M, Soga A, Nishito Y, Ando H, Hashimoto H, Petris MJ, Kinoshita M, Kambe T.

概要

Tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) are essential for pigmentation. They are generally classified as type-3 copper proteins, with binuclear copper active sites. Although there is experimental evidence for a copper cofactor in TYR, delivered via the copper transporter, ATP7A, the presence of copper in TYRP1 and TYRP2 has not been demonstrated. Here, we report that the expression and function of TYRP1 requires zinc, mediated by ZNT5-ZNT6 heterodimers (ZNT5-6) or ZNT7-ZNT7 homodimers (ZNT7). Loss of ZNT5-6 and ZNT7 function results in hypopigmentation in medaka fish and human melanoma cells, and is accompanied by immature melanosomes and reduced melanin content, as observed in TYRP1 dysfunction. The requirement of ZNT5-6 and ZNT7 for TYRP1 expression is conserved in human, mouse, and chicken orthologs. Our results provide novel insights into the pigmentation process and address questions regarding metalation in tyrosinase protein family.

発表雑誌等の名称

Commun. Biol.

出版者

6

1

開始ページ

403

終了ページ

発行又は発表の年月

2023/04

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

10.1038/s42003-023-04640-5

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID