論文

基本情報

氏名 目加田 和之
氏名(カナ) メカダ カズユキ
氏名(英語) Mekada Kazuyuki
所属 理学部 動物学科
職名 教授
researchmap研究者コード 5000072882
researchmap機関 岡山理科大学

題名

Substrains matter in phenotyping of C57BL/6.

単著・共著の別

共著

著者

K. Mekada, A. Yoshiki

概要

The inbred mouse strain C57BL/6 has been widely used as a background strain for spontaneous and induced mutations. Developed in the 1930s, the C57BL/6 strain diverged into two major groups in the 1950s, namely, C57BL/6J and C57BL/6N, and more than 20 substrains have been established from them worldwide. We previously reported genetic differences among C57BL/6 substrains in 2009 and 2015. Since then, dozens of reports have been published on phenotypic differences in behavioral, neurological, cardiovascular, and metabolic traits. Substrains need to be chosen according to the purpose of the study because phenotypic differences might affect the experimental results. In this paper, we review recent reports of phenotypic and genetic differences among C57BL/6 substrains, focus our attention on the proper use of C57BL/6 and other inbred strains in the era of genome editing, and provide the life science research community wider knowledge about this subject.

発表雑誌等の名称

Experimental Animals

出版者

70

開始ページ

145

終了ページ

160

発行又は発表の年月

2021/05

査読の有無

有り

招待の有無

無し

記述言語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID