論文

基本情報

氏名 目加田 和之
氏名(カナ) メカダ カズユキ
氏名(英語) Mekada Kazuyuki
所属 理学部 動物学科
職名 教授
researchmap研究者コード 5000072882
researchmap機関 岡山理科大学

題名

Complete sequencing of the mouse pseudoautosomal region, the most rapidly evolving ‘chromosome’

単著・共著の別

共著

著者

Kasahara T., Mekada K., Abe K., Ashworth A., Kato T.

概要

The pseudoautosomal region (PAR) of mammalian sex chromosomes is a small region of sequence identity that allows pairing, crossover, recombination, and proper chromosome segregation during male meiosis. The structure of the mouse PAR is largely unknown. Here, we developed a new assembly method to robustly resolve repetitive sequences and employed highly accurate long-read sequencing data to reveal the entire PAR sequence. The PAR of the widely-used inbred strain C57BL/6J is ∼700 kb, comprising 10 protein- coding genes in a mass of complex repetitive sequences. A large segmental duplication exhibiting copy-number polymorphisms even among C57BL/6J littermates is present. High GC-content exons and short introns are common properties of PAR genes and are the consequence of maintaining gene function, while PAR is rapidly evolving. Elucidating the mouse PAR sequence completes the mouse euchromatic genome sequencing and enables the exploration of the function and evolution of the PAR using modern molecular genetic approaches.

発表雑誌等の名称

bioRxiv

出版者

48593

開始ページ

終了ページ

発行又は発表の年月

2022/03

査読の有無

無し

招待の有無

無し

記述言語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID