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| 基本情報 |
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| 氏名 |
清水 一郎 |
| 氏名（カナ） |
ｼﾐｽﾞ ｲﾁﾛｳ |
| 氏名（英語） |
Shimizu Ichiro |
| 所属 |
工学部 機械ｼｽﾃﾑ工学科 |
| 職名 |
教授 |
| researchmap研究者コード |
1000187306 |
| researchmap機関 |
岡山理科大学 |
Effect of Parylene C on the Corrosion Resistance of Bioresorbable Cardiovascular Stents Made of Magnesium Alloy ‘Original ZM10’
Makoto Sasaki, Wei Xu, Yuki Koga, Yuki Okazawa, Akira Wada, Ichiro Shimizu and Takuro Niidome
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Magnesium (Mg) alloy has attracted significant attention as a bioresorbable scaffold for use as a next-generation stent because of its mechanical properties and biocompatibility. However, Mg alloy quickly degrades in the physiological environment. In this study, we investigated whether applying a parylene C coating can improve the corrosion resistance of a Mg alloy stent, which is made of 'Original ZM10', free of aluminum and rare earth elements. The coating exhibited a smooth surface with no large cracks, even after balloon expansion of the stent, and improved the corrosion resistance of the stent in cell culture medium. In particular, the parylene C coating of a hydrofluoric acid-treated Mg alloy stent led to excellent corrosion resistance. In addition, the parylene C coating did not affect a polymer layer consisting of poly(ε-caprolactone) and poly(D,L-lactic acid) applied as an additional coating for the drug release to suppress restenosis. Parylene C is a promising surface coating for bioresorbable Mg alloy stents for clinical applications.
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