論文

基本情報

氏名 千葉 秀一
氏名(カナ) チバ シュウイチ
氏名(英語) Chiba Shuichi
所属 獣医学部 獣医学科
職名 講師
researchmap研究者コード 5000090589
researchmap機関 岡山理科大学

題名

Rotigotine, a dopamine receptor agonist, increased BDNF protein levels in the rat cortex and hippocampus

単著・共著の別

著者

Adachi N,  Yoshimura A,  Chiba S,  Ogawa S,  Kunugi H.

概要

Brain-derived neurotrophic factor (BDNF) critically controls the fate and function of the neuronal network and has received much attention as a target of many brain diseases. Dopaminergic system dysfunction has also been implicated in a variety of neuropsychiatric diseases. Rotigotine, a non-ergot dopamine receptor agonist, is used in the treatment of Parkinson's disease and restless legs syndrome. To investigate the effects of rotigotine on neuronal functions both in vivo and in vitro, rats and primary cortical neurons were administered rotigotine, and the mRNA and protein expression levels of BDNF, its receptor TrkB and downstream signaling molecules, and synaptic proteins were determined. We found that BDNF protein was increased in the cortex and hippocampus of rats after 7days of rotigotine treatment. In contrast, BDNF mRNAs were reduced 6hours after rotigotine treatment in cultured neurons presumably through the transient suppression of neuronal activity. We identified differential expression of D1, D2, and D3 receptors in the rat brain and cultured neurons. The observed increase in the expression of BDNF protein in the cortex and hippocampus after subchronic administration of rotigotine suggests that it may exert its medical effect in part through improving BDNF function in the brain. In addition, our results highlight the complex relationships between rotigotine and BDNF expression, which depend on the brain region, time course, and dose of the drug.

発表雑誌等の名称

Neuroscience Letters

出版者

662

開始ページ

44

終了ページ

50

発行又は発表の年月

2017/10

査読の有無

有り

招待の有無

無し

記述言語

英語

掲載種別

研究論文(学術雑誌)

ISSN

ID:DOI

ID:NAID(CiNiiのID)

ID:PMID

URL

JGlobalID

arXiv ID

ORCIDのPut Code

DBLP ID