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基本情報
| 氏名 |
水野 信哉 |
| 氏名（カナ） |
ﾐｽﾞﾉ ｼﾝﾔ |
| 氏名（英語） |
Mizuno Shinya |
| 所属 |
理学部 動物学科 |
| 職名 |
教授 |
| researchmap研究者コード |
B000267899 |
| researchmap機関 |
岡山理科大学 |
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- 2018/10 Kinase phosphorylation-based mechanisms of PARP inhibitor resistance during synthetic lethal oncotherapy. Ohsaki Eriko and Mizuno Shinya Current Signaling Transduction Therapy 13: 1-12 (2018)
- 2018/08 細胞増殖因子から見た低温医学研究ならびに冬眠研究 水野信哉、大﨑恵理子 細胞 40(8) 48 - 50
- 2018 DNA-Checkpoint Kinase, ATR is a promising target for synthetic lethality-aimed anti-tumor therapy. Mizuno Shinya and Ohsaki Eriko J Tumor Research 4: 1-3 (2018)
- 2018 Poly (ADP-Ribose) Polymerase (PARP), an emerging target for controlling metastatic prostate cancer under BRCAness. Mizuno Shinya and Ohsaki Eriko J Oncology Translational Research 4: 1-3 (2018)
- 2018 Poly(ADP-ribose) polymerase (PARP)-based biology and pharmacology for clinical oncotherapy. Ohsaki Eriko and Mizuno Shinya J Translational Science 4: 1-3 (2018)
- 2017 Nephron, Wilms' tumor-1 (WT1), and synaptopodin expression in developing podocytes of mice. Kato T and Mizuno S Exp Animal 66: 183-189 (2017)
- 2016 Up-regulation of local TGF-beta contributes to a decrease in renal tubular Na+ K+ ATPase and hyperkalemia in a mouse model of crush syndrome. Mizuno S and Mizuno-Horikawa Y. Pharmacology and Pharmacy 7: 481-492 (2016)
- 2015 Stromal cell-derived factor-1 (SDF1) dependent recruitment of bone marrow-derived renal endothelium-like cells in a mouse model of acute kidney injury. Ohnishi-H, Mizuno S*, Mizuno-Horikawa H and Kato T. J Vet Med Sci 77: 313-319 (2015)
- 2014 A decrease in glomerular endothelial cells and endothelial mesenchymal transition during glomerulosclerosis in the tensin2-deficient mice (ICGN strain). Kato T, Mizuno S and Ito A Acta Histochem Cytochemi, 47: 265-271 (2014)
- 2013 Dissociation of c-Met phospho-tyrosine sites in human cells in response to mouse HGF, but not human HGF: The possible roles of different amino acids in different species. Ikebuchi F, Oka K, Mizuno S, Fukuta K, Hayata D, Ohnishi H and Nakamura T. Cell Biochem Function 31: 298-304 (2013)
- 2013 Up-regulation of cyclin-E1 via proline-mTOR pathway is responsible for HGF-mediated G1/S progression in the primary culture of rat hepatocytes. Oka K, Ohya-Shimada W, Mizuno S and Nakamura T. Biochem Biophys Res Communs 435: 120-125 (2013)
- 2012 Hepatocyte growth factor (HGF) overexpression in the nervous system enhances learning and memory performance in mice. Kato T, Funakoshi H, Kadoyama K, Noma S, Kanai M, Ohya-Shimada, W, Mizuno S, Doe N, Taniguchi T and Nakamura T. J Neurosci Res 90: 1743-1755 (2012)
- 2012 Identification of mannose receptor as a receptor for HGF β-chain: A novel ligand-receptor pathway for enhancing macrophage phagocytosis. Ohnishi H, Oka K, Mizuno S and Nakamura T. J Biol Chem 287: 13371-13381 (2012)
- 2011 Decreases in podocin, CD2-associated protein (CD2AP) and tensin2 may be involved in albuminuria during septic acute renal failure. Kato T, Mizuno-Horikawa-Y and Mizuno S. J Vet Med Sci 73: 1579-1584 (2011)
- 2011 Preservations of nephrin and synaptopodin by HGF in podocytes for the attenuations of foot process injury and albuminuria in nephritic mice. Kato T, Mizuno S and Nakamura T. Nephrology 16: 310-318 (2011)
- 2011 Recombinant human HGF, but not rat HGF, elicits glomerular injury and albuminuria in normal rats via an immune complex-dependent mechanism. Mizuno S, Ikebuch F, Fukuta K, Kato T, Matsumoto K, Adachi K, Abe T and Nakamura T. Clin Exp Pharmacol Physiol 38: 192-201 (2011)
- 2010 Attenuation of ischemic myocardial injury and dysfunction by cardiac fibroblast-derived factor(s). Nakazato K, Naganuma W, Ogawa K, Yaoita H, Mizuno S, Nakamura T and Maruyama Y. ukushima J Med Sci 56: 1-16 (2010)
- 2010 The decreases of nephrin and nuclear WT1 in podocytes may cause albuminuria during the experimental sepsis in mice. Kato T, Mizuno S* and Kamimoto M. Biomed Res 31: 363-369 (2010)
- 2009 Hepatocyte growth factor prevents multiple organ injuries in endotoxemic mice through a heme oxygenase-dependent mechanism. Kamimoto M, Mizuno S, Matsumoto K and Nakamura T. Biochem Biophys Res Communs 380: 333-337 (2009)
- 2009 Injection of HGF plasmid cDNA to prevent manifestation of Parkinson disease: a preclinical study using a primate model. Koike H, Ishida A, Hayashi T, Shimamura M, Mizuno S, Nakamura T, Iida H, Ogihara T, Kaneda Y, Morishita R. Open Gene Therapy Journal 2: 38-44 (2009)
- 2009 Reciprocal regulation of IL-6 and Il-10 balance by HGF via recruitment of HO-1 in macrophages for attenuation of hepatic injury in a mouse model of endotoxemia. Kamimoto M, Mizuno S and Nakamura T. Int J Mol Med 24: 161-170 (2009)
- 2009 Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models. Kishi Y, Kuba K, Nakamura T, Wen J, Suzuki Y, Mizuno S, Nukiwa T, Matsumoto K and Nakamura T. Cancer Sci 100: 1351-1358 (2009)
- 2009 Type 2a sodium phosphate co-transporter serves as a histological predictor of renal dysfunction and tubular apical damage in the kidney of septic mice. amimoto M, Mizuno S*, Ohnishi H and Mizuno-Horikawa Y. Biomed Res 30: 251-258 (2009)
- 2008 Growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice. Ito W, Tanimoto M, Ono K, Mizuno S, Yoshida A, Koga H, Fuchimoto Y, Kondo N, Tanimoto Y, Kiura K, Matsumoto K, Kataoka M, Nakamura T, Gelfand EW and Kanehiro A. Int Arch Allergy Immunol 145: 324-339 (2008)
- 2008 Inhibition of tubular cell proliferation by neutralizing endogenous HGF leads to renal hypoxia and bone marrow-derived cell engraftment in renal failure of mice. Ohnishi H, Mizuno S and Nakamura T. Am J Physiol, 294: F326-F335 (2008)
- 2008 Intranasal HGF administration ameriorates the physiological and morphological changes in lung emphysema. Hegab AE, Kubo H, Hayama M, Asada M, He M, Mizuno S and Nakamura T. Mol Therapy 16: 1417-1426 (2008)
- 2008 The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice. Kato T, Mizuno-S*, Taketo MM and Kurosawa T. Biomed Res 29: 279-287 (2008)
- 2008 Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice. Kanai M, Funakoshi H, Takahashi H, Hayakawa T, Mizuno S, Matsumoto K and Nakamura T. Mol Brain 2: 8-23 (2009)
- 2007 Anti-necrotic and anti-apoptotic effects of HGF on cholestatic hepatitis in a mouse model of bile congestive diseases. Li Z, Mizuno S, and Nakamura T. Am J Physiol, 292: G639-G646 (2007)
- 2007 Attenuation of glycerol-induced acute kidney injury by previous partial hepatectomy: Role of hepatocyte growth factor/c-met axis in tubular protection. Homsi E, Janino P, Biswas SW, Mizuno S, Nakamura T and Lopes de Faria JB. Nephron Experiment, 107: e95-e106 (2007)
- 2007 Hepatocyte growth factor prevents pulmonary ischemia-reperfusion injury in mice. Makiuchi A, Yamaura K, Mizuno S, Matsumoto K, Nakamura T, Amano J and Ito K. J Heart Lung Transplant 26: 935-943 (2007)
- 2006 Autologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysema. Shigemura N, Okumura M, Mizuno S, Imanishi Y, Nakamura T and Sawa Y. Am J Transplant 6: 2592-2600 (2006)
- 2006 Endothelial progenitor cell transplantation improves the survival following liver injury in mice. Taniguchi E, Kin M, Torimura T, Nakamura T, Kumemura H, Hanada S, Hisamoto T, Yoshida T, Kawaguchi T, Baba S, Maeyama M, Koga H, Harada M, Kumashiro R, Ueno T, Mizuno S, Ikeda H, Imaizumi T, Murohara T, Sata M. Gastroenterology 130: 521-531 (2006)
- 2006 Lung tissue engineering technique with adipose tissue-derived stromal cells improves surgical outcomes for pulmonary emphysema. Shigemura N, Okumura M, Mizuno S, Imanishi Y, Matsuyama A, Shiono H, Nakamura T, and Sawa Y. Am J Respir Crit Care Med 174: 1199-1205 (2006)
- 2006 Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease. Koike H, Ishida A, Shimamura M, Mizuno S, Nakamura T, Ogihara T, Kaneda Y, and Morishita R. Gene Therapy, 13: 1639-1644 (2006)
- 2006 The loss of local HGF, an endogenous gastrophic factor, leads to mucosal injuries in the stomach of mice. Nakahira R, Mizuno S, Yoshimine T and Nakamura T. Biochem Biophys Res Communs, 341: 897-903 (2006)
- 2005 A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. Okunishi K, Dohi M, Nakagome K, Tanaka R, Mizuno S, Matsumoto K, Miyazaki J, Nakamura T and Yamamoto K. J Immunol 175: 4745-4753 (2005)
- 2005 Amelyoration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats. Shigemura N, Sawa Y, Mizuno S, Ono M, Ohta M, Nakamura T, Kaneda Y and Matsuda H. Circulation 111: 1407-1414 (2005)
- 2005 HGF reduces advancing lung fibrosis in mice: a potential role for MMP-dependent myofibroblast apoptosis. 45. Mizuno S, Matsumoto K, Li MY and Nakamura T. FASEB J 19: 580-582 (2005)
- 2005 Hepatocyte growth factor amryorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper2 cytokines. Futamastu H, Suzuki J, Mizuno S, Koga N, Adachi S, Kosuge H, Maejima Y, Hirao K, Nakamura T and Isobe M. Circulation Res 96: 823-830 (2005)
- 2005 Hepatocyte growth factor contributes to fracture repair by up-regulating the expression of bone morphogenetic protein receptors. Imai Y, Terai H, Nomura-Furuwatari C, Mizuno S, Matsumoto K, Nakamura T and Takaoka K. J Bone Miner Res 20: 1723-1730 (2005)
- 2005 Hepatocyte growth factor prevents tissue fibrosis, remodeling and dysfunction in cardiomyopathic hamster hearts. Nakamura T, Matsumoto K, Mizuno S, Sawa Y, Matsuda H and Nakamura T. Am J Physiol, 288: H2131-2139 (2005)
- 2005 Induction of compensatory lung growth in pulmonary emphysema improves surgical outcomes in rats. Shigemura N, Sawa Y, Mizuno S, Ono M, Minami M, Okumura M, Nakamura T, Kaneda Y and Matsuda H. Am J Respir Crit Care Med 171: 1237-1245 (2005)
- 2005 Prevention of neutrophil extravasation by HGF leads to attenuations of tubular apoptosis and renal dysfunction in mouse ischemic kidneys. Mizuno S and Nakamura T. Am J Pathol 166: 1895-1905 (2005)
- 2004 Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity. Mizui M, Isaka Y, Takabatake Y, Mizuno S, Nakamura T, Ito T, Imai E and Hori M. Kidney Int 65: 2041-2053 (2004)
- 2004 HGF gene transfer in cerebrospinal fluid can prevent hearing impairment in rats. Oshima K, Shimamura M, Mizuno S, Tamami K, Doi K, Morishita R, Nakamura T, Kubo T and Kaneda Y. FASEB J 18: 212-214 (2004)
- 2004 Hepatocyte growth factor induces angiogenesis in injured lungs through mobilizing endothelial progenitor cells. Ishizawa K, Kubo H, Yamada M, Kobayashi S, Suzuki T, Mizuno S, Nakamura T and Sasaki H. Biochem Biophys Res Communs 324: 276-280 (2004)
- 2004 Hepatocyte growth factor suppresses vascular medial hyperplasia and matrix accumulation in advanced pulmonary hypertension of rats. Ono M, Sawa Y, Mizuno S, Fukushima N, Ichikawa H, Bessho K, Nakamura T and Matsuda H. Circulation 110: 2896-2902 (2004)
- 2004 Myocardial protective effect of human recombinant hepatocyte growth factor for prolonged heart graft preservation in rats. Ryugo M, Sawa Y, Ono M, Alechine1 AN, Mizuno S, Nakamura T and Matsuda H. Transplantation 78: 1153-1158 (2004)
- 2004 Repeated streptozotocin injections cause early onset of glomerulosclerosis in mice. Mizuno S*, Wen J and Mizuno-Horikawa Y. Exp Anim 53: 175-180 (2004)
- 2004 Steroid therapy delays the progression of glomerular sclerosis but not nephrotic symptoms in the ICGN mouse strain. Mizuno S* and Kurosawa T. Vet Biochem 40: 55-61 (2004)
- 2004 Suppression of chronic glomerular injuries and TGF-beta1 production by HGF in attenuation of murine diabetic nephropathy. Mizuno S and Nakamura T. Am J Physiol 286: F134-143 (2004)
- 2004 The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism. Hattori N, Mizuno S, Yoshida Y, Chin K, Mishima M, Sisson TH, Simon RH, Nakamura T, and Miyake M. Am J Pathol 164: 1091-1098 (2004)
- 2003 Counteractive effects of HGF on PDGF-induced mesangial cell proliferation in a rat model of glomerulonephritis. Bessho K, Mizuno S, Matsumoto K and Nakamura T. Am J Phsiol 284: F1171-F1180 (2003)
- 2002 Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice. Sakamaki Y, Matsumoto K, Mizuno S, Miyoshi S, Matsuda H and Nakamura T. Am J Respir Cell Mol Biol 26: 525-533 (2002)
- 2002 Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction. Sawashima K, Mizuno S, Mizuno-Horikawa Y and Kurosawa T. Exp Nephrol 10: 7-18 (2002)
- 2001 Advanced glomerulosclerosis is reversible in nephrotic mice. Mizuno-Horikawa Y, Mizuno S and Kurosawa T. Biochem Biophys Res Communs 284: 707-713 (2001)
- 2001 Hepatocyte growth factor suppresses tubulo-interstitial fibrosis in a mouse model of obstructive nephropathy. Mizuno S, Matsumoto K and Nakamura T. Kidney Intl 59: 1304-1314 (2001)
- 2001 Immunohistochemical analysis of molecular events in tubulo-interstitial fibrosis in a mouse model of diffuse mesangial sclerosis (ICGN strain). Mizuno S*, Mizuno-Horikawa Y and Kurosawa T. J Vet Med Sci 63: 299-307 (2001)
- 2000 Enhanced expression of hepatocyte growth factor by pulmonary ischemia reperfusion injury in the rats. Yamada T, Hisanaga M, Mizuno S, Matsumoto K, Nakamura T and Nakano H. Am J Respir Crit Care Med 162: 707-715 (2000)
- 2000 Expression of alpha-smooth muscle actin and fibronectin in the tubulo-interstitial lesions of cats with chronic renal failure. Sawashima K, Mizuno S, Mizuno-Horikawa Y, Shimada A, Kudo T and Kurosawa T. Am J Vet Res 61: 1080-1086 (2000)
- 2000 IL-2-dependent growth of canine anti-tumor lymphocytes: Comparison of human IL-2 with dog IL-2. Mizuno S*, Kurosawa T and Fujinaga T. Anim Biochem 36: 39-45 (2000)
- 2000 Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. Nakamura T, Mizuno S, Matsumoto K, Sawa Y, Matsuda H and Nakamura T. J Clin Invest 106: 1511-1519 (2000)
- 2000 Reciprocal balance of hepatocyte growth factor and transforming growth factor-beta1 in renal fibrosis in mice. Mizuno S, Matsumoto K, Kurosawa T, Mizuno-Horikawa Y and Nakamura T. Kidney Intl 57: 937-948 (2000)
- 1999 Nephrotic mice (ICGN strain): A Model of diffuse mesangial sclerosis in infantile nephrotic syndrome. Mizuno S, Mizuno-Horikawa Y, Yue BF, Okamoto M and Kurosawa T. Am J Nephrol 19: 73-82 (1999)
- 1998 Angiotensin-converting enzyme inhibitor suppresses tubular expression of platelet-derived growth factor and attenuates progression of interstitial fibrosis in a nephrotic mouse model. Mizuno S, Mizuno-Horikawa Y, Okamoto M and Kurosawa T. Nephron 79: 503-504 (1998)
- 1998 Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. Mizuno S, Kurosawa T, Matsumoto K, Mizuno-Horikawa Y, Okamoto M and Nakamura T. J Clin Invest 101: 1827-1834 (1998)
- 1998 Invention of a force-air-ventilated micro-isolation cage and rack system environment within cages: Temperature and ammonia concentration. Ishii T, Yoshida K, Hasegawa M, Mizuno S, Okamoto M, Tajima M and Kurosawa T. Appl Anim Behaviour Sci 59: 115-123 (1998)
- 1998 Preventive effects of ACE inhibitor on interstitial myofibroblast formation and matrix deposition in a nephrotic model. Mizuno S*, Horikawa Y, Okamoto M and Kurosawa T. Renal Failure 20: 481-491 (1998)
- 1998 Sevoflurane face mask anesthesia in rabbits: A comparison of 3%-sevoflurane with 3%-halothane. Kurosawa T, Matsuda Y, Okamoto M and Mizuno S. J Exp Anim Sci 39: 1-13 (1998)
- 1997 Diffuse glomerulosclerosis without tubular injury does not manifest renal dysfunction in nephrotic mice (ICGN strain). Mizuno S, Yue BF, Okamoto M, Horikawa Y and Kurosawa T. Exp Nephrol 5: 498-507 (1997)
- Augmentative effects of phytohemagglutinin-P on proliferation and cytotoxicity of interleukin-2-activated canine peripheral blood lymphocytes. Mizuno S*, Fujinaga T and Kurosawa T. J Vet Med A 43: 289-296 (1996)
- Changes in lymphokine-activated killer activity in peripheral blood lymphocytes of canine transmissible venereal sarcoma models. Mizuno S*, Fujinaga T and Kurosawa T. Exp Anim 45: 289-292 (1996)
- Characterization of dog interleukin-2 activity. Mizuno S*, Fujinaga T and Hagio M. J Vet Med Sci 55: 925-930 (1993)
- Chromosome analysis of canine transmissible sarcoma cells. Fujinaga T, Yamashita M, Yoshida MC, Mizuno S, Okamoto Y, Tajima M and Otomo K. J Vet Med A 36: 481-489 (1989)
- Equine haptoglobin: Isolation and characterization, and the effects of aging, delivery and inflammation on its serum concentration. Taira T, Fujinaga T, Okumura M, Yamashita K, Tsunoda N and Mizuno S. J Vet Med Sci 54: 435-442 (1992)
- Isolation and characterization of a-acid glycoprotein from horses, and its evaluation as an acute-phase reactive protein in horses. Taira T, Fujinaga T, Tamura K, Izumi M, Itoh H, Tsunoda N, Yamashita K, Okumura M and Mizuno S. Am J Vet Res 53: 961-965 (1992)
- Isolation, characterization and quantitative analysis of C-reactive protein from horses. Takiguchi M, Fujinaga T, Naiki M, Mizuno S and Otomo K. Am J Vet Res 51: 1215-1220 (1990)
- Isolation, characterization, and quantitative analysis of ceruloplasmin from horses. Okumura M, Fujinaga T, Yamashita K, Tsunoda N and Mizuno S. Am J Vet Res 52: 1979-1985 (1991)
- Pathological study of lead poisoning in whooper swans (Cygnus cygnus) in Japan. Ochiai K, Jin K, Itakura C, Goryo M, Yamashita K, Mizuno S, Fujinaga T and Tsuzuki T. Avian Diseases 36: 313-323 (1992)
- Role of lymphocytes in dogs experimentally rechallenged with canine transmissible sarcoma. Mizuno S*, Fujinaga T, Tajima M, Otomo K and Koike T. Jpn J Vet Sci 51: 86-95 (1989)
- Role of lymphocytes in spontaneous regression of experimentally transplanted canine transmissible venereal sarcoma. Mizuno S*, Fujinaga T and Hagio M. J Vet Med Sci 56: 15-20 (1994)
- Serum C-reactive protein (CRP) in horses: The effect of aging, sex, delivery and inflammation on its concentration. Yamashita K, Fujinaga T, Okumura M, Takiguchi M, Tsunoda N and Mizuno S. J Vet Med Sci 53: 1019-1024 (1991)
- The banding patterns of normal canine chromosomes. Fujinaga T, Yamashita M, Yoshida MC, Mizuno S, Tajima M, Okamoto Y and Otomo K. Jpn J Vet Sci 51: 294-299 (1989)
- The distributions of phytohemagglutinin-P and concanavalin A binding sites on equine, bovine and canine peripheral blood lymphocytes. Tajima M, Fujinaga T, Mizuno S and Otomo K. J Vet Med B 37: 290-296 (1990)
- 低温医学と冬眠科学をつなぐ増殖因子の役割 水野信哉, 大﨑恵理子
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