Inorganic silica hybrid octacalcium phosphate bone substitute: Harmonics to acceleration in biological metabolism and its curing process

Yuki Sugiura, Fumiko Ono, Masakatsu Nohara, Ayumu Takechi, Kenji Kutara, Teppei Kanda, Yasuko Saito, Etsuko Yamada, Kazuo Oowada, Takashi Endo, Masanori Horie, Yoji Makita

Previously, assembling and developing a compatible bone remodeling process had been a dogma for bone substitute fabrication. However, considering patients who use such bone substitutes, such as elderly people, the major problem is poor bone remodeling, which has been a significant disadvantage limiting active intervention. Therefore, in this study, we introduced a new concept for bone substitutes, namely, a continuous up-regulating bone remodeling process using implanted materials for a rapid curing process. Using an ionic insertion method, inorganic silica, and a viability-controlled factor for bone remodeling, we fabricated octacalcium phosphate (OCP) with silica (OCP-silica) blocks as bone substitutes. The fabricated OCP-silica blocks consisted of hieratical silica and OCP structures at an atomic scale. In vivo experimental results indicated that these OCP-silica blocks enhanced bone remodeling and almost completely replaced all bone tissues in only 3 months compared with existing bone replacement-type bone substitutes.

Materialia