|
|
|
| 基本情報 |
|
| 氏名 |
神林 康弘 |
| 氏名（カナ） |
ｶﾝﾊﾞﾔｼ ﾔｽﾋﾛ |
| 氏名（英語） |
Kambayashi Yasuhiro |
| 所属 |
獣医学部 獣医学科 |
| 職名 |
教授 |
| researchmap研究者コード |
5000036919 |
| researchmap機関 |
岡山理科大学 |
Serum TNFα and IL-17A levels may predict increased depressive symptoms: findings from the Shika Study cohort project in Japan
Hirohito Tsuboi1,2,3* , Hiroyuki Sakakibara4, Yuuki Minamida‐Urata2, Hiromasa Tsujiguchi3, Akinori Hara3, Keita Suzuki3, Sakae Miyagi6, Masaharu Nakamura3, Chie Takazawa3, Takayuki Kannon7, Jiaye Zhao3, Yukari Shimizu8, Aki Shibata3, Aya Ogawa3, Fumihiko Suzuki9, Yasuhiro Kambayashi10, Tadashi Konoshita11, Atsushi Tajima5 and Hiroyuki Nakamura3
|
 |
Background Low‐grade systemic inflammation may be a key player in the immune activation that has been reported for mental health deterioration. We hypothesised that elevated serum levels of inflammatory cytokines increase neuroinflammation and exacerbate depressive symptoms.
Methods The participants were part of a cohort study for whom data was available for both 2015 and 2019. In 2015,
blood samples were collected from 232 participants. Their depressive symptoms were assessed both 2015 and 2019
using the Centre for Epidemiologic Studies Depression Scale (CES‐D) (n = 33). The multiplex immunoassay system ®
(Luminex 200) was used to measure the serum concentrations of IL‐6, IL‐10, IL‐12, IL‐17A and TNFα. Data were ana‐ lysed using linear models with the level of significance considered to be p < 0.05.
Results After controlling for age, BMI, smoking and alcohol consumption, in 2015 the serum concentrations of IL‐17A and TNFα in 2015 were significantly positively associated with the CES‐D scores of women (standardised β (B) = .027,
p < 0.01 and B = 0.26, p < 0.01, respectively). The serum concentrations of IL‐17A and TNFα of men were significantly positively associated with the CES‐D scores of 2019 (B = 0.62, p = 0.02 and B = 0.59, p = 0.02, respectively).
Conclusions In this cross‐sectional study, we found a significant positive correlation between the depressive symptoms and serum TNFα and IL‐17A levels of women. In addition, our longitudinal findings suggest the possibility that TNFα and IL‐17A could elevate the depressive symptoms of men.
Keywords Low‐grade inflammation, Depressive symptoms, Inflammatory cytokines, Interleukin (IL)‐17, Tumour necrosis factor (TNF)α, Community‐based cohort study
|
