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| 基本情報 |
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| 氏名 |
神林 康弘 |
| 氏名（カナ） |
ｶﾝﾊﾞﾔｼ ﾔｽﾋﾛ |
| 氏名（英語） |
Kambayashi Yasuhiro |
| 所属 |
獣医学部 獣医学科 |
| 職名 |
教授 |
| researchmap研究者コード |
5000036919 |
| researchmap機関 |
岡山理科大学 |
IL-6 and TNFα are associated with depressive symptoms among men in a community-based cohort, with a tentative trend for IL-17A: Findings from the Shika Study in Japan
Hirohito Tsuboi 1 2 , Hiroyuki Sakakibara 3 , Yuuki Minamida-Urata 2 , Yui Takakura 2 , Hiromasa Tsujiguchi 1 , Akinori Hara 1 , Keita Suzuki 4 , Sakae Miyagi 5 , Masaharu Nakamura 1 , Chie Takazawa 1 , Takayuki Kannon 6 , Jiaye Zhao 1 , Yukari Shimizu 7 , Aki Shibata 1 , Aya Ogawa 1 , Fumihiko Suzuki 8 , Yasuhiro Kambayashi 9 , Atsushi Tajima 4 , Hiroyuki Nakamura 1
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Objective: Emerging evidence suggests that low-grade systemic inflammation contributes to depressive symptoms; however, population-based longitudinal evidence, particularly from community samples, remains limited. This study examined the associations between serum cytokine levels and depressive symptoms among community-dwelling adults in Japan.
Participants and methods: Participants were drawn from the Shika Study cohort (N = 182; 98 men, 84 women; mean age: 62.2 ± 9.34 years for men, 60.9 ± 9.49 for women). They provided blood samples in 2017 and completed the Japanese versions of the Center for Epidemiologic Studies Depression Scale (CES-D) in 2017 and its revised version (CESD-R) in 2019. Serum TNFα, IL-6, IL-10 and IL-17A were quantified using a multiplex human immunoassay.
Results: Among men, serum IL-6 levels were positively associated with CES-D scores in 2017 after adjustment for age, visceral adiposity, smoking, and alcohol consumption (standardised regression coefficient (β) = 0.25, p = 0.024). Baseline TNF-α was significantly associated with higher CES-D-R scores in 2019 (β = 0.23, p = 0.026), whereas IL-17A showed only a non-significant trend (β = 0.13, p = 0.231). No significant associations were observed among women or for IL-10.
Conclusion: In this exploratory community-based study, higher IL-6 levels were modestly associated with concurrent depressive symptoms in men, and baseline TNFα showed a similarly modest association with depressive symptoms two years later as measured by the CESD-R. IL-17A showed a tentative trend that requires replication. These findings suggest possible sex-specific links between peripheral inflammation and depressive symptoms, but the results should be interpreted as hypothesis generating.
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