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| 基本情報 |
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| 氏名 |
神林 康弘 |
| 氏名（カナ） |
ｶﾝﾊﾞﾔｼ ﾔｽﾋﾛ |
| 氏名（英語） |
Kambayashi Yasuhiro |
| 所属 |
獣医学部 獣医学科 |
| 職名 |
教授 |
| researchmap研究者コード |
5000036919 |
| researchmap機関 |
岡山理科大学 |
Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men
Sakae Miyagi, Toshinari Takamura, Thao Thi Thu Nguyen, Hiromasa Tsujiguchi, Akinori Hara, Haruki Nakamura, Keita Suzuki, Atsushi Tajima, Takayuki Kannon, Tadashi Toyama, Yasuhiro Kambayashi, and Hiroyuki Nakamura
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Aims/introduction: A low insulin secretion capacity has been implicated in the high prevalence of non-obese diabetes in East Asians. As alcohol consumption alters insulin and glucose metabolism, we tested the hypothesis that alcohol consumption contributes to impaired insulin secretion and glucose intolerance in lean/normal-weight non-diabetic Japanese men.Materials and methods: This cross-sectional study was undertaken among the residents of Shika town, Japan, between 2011 and 2017. A total of 402 non-diabetic men, including participants with normal fasting plasma glucose (FPG) and impaired FPG (FPG 5.6-6.9 mmol/L), and aged ≥40 years, were examined. FPG, the homeostasis model assessment of insulin secretion capacity (HOMA-B) and alcohol consumption were evaluated and compared between the body mass index (BMI) <25 and BMI ≥25 groups.
Results: HOMA-B levels were lower in the BMI <25 group than in the BMI ≥25 group. Alcohol consumption correlated with a low HOMA-B level regardless of BMI, and, thus, the HOMA-B levels of alcohol drinkers were significantly lower in the BMI <25 group. A multivariable logistic regression analysis showed that alcohol consumption, even light-to-moderate consumption (1-25 g/day), was associated with significantly low levels of HOMA-B and impaired FPG in the BMI <25 group. Among participants with impaired FPG, a low level of HOMA-B was observed in alcohol drinkers, but not in non-drinkers. In contrast, light-to-moderate alcohol consumption was not related to HOMA-B or FPG in the BMI ≥25-group.
Conclusion: Alcohol consumption, even a small amount, might contribute to reductions in HOMA-B levels and impaired FPG in lean/normal-weight Japanese men.
Keywords: Alcohol drinking; Body size; Insulin secretion.
Journal of Diabetes Invesrtigation
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