Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population

Youhei Yamada  1   2 , Haruki Nakamura  1 , Hiromasa Tsujiguchi  1   2   3 , Akinori Hara  1   2   3 , Sakae Miyagi  4 , Takayuki Kannon  3   5 , Takehiro Sato  3   5 , Kazuyoshi Hosomichi  3   5 , Thao Thi Thu Nguyen  6 , Yasuhiro Kambayashi  7 , Yukari Shimizu  8 , Kim Oanh Pham  1 , Keita Suzuki  1   2 , Fumihiko Suzuki  1 , Tomoko Kasahara  1   2 , Hirohito Tsuboi  9 , Atsushi Tajima  3   5 , Hiroyuki Nakamura  1   2   3

A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.

PLOS ONE

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