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基本情報
| 氏名 |
原村 昌幸 |
| 氏名（カナ） |
ﾊﾗﾑﾗ ﾏｻﾕｷ |
| 氏名（英語） |
Haramura Masayuki |
| 所属 |
生命科学部 生物科学科 |
| 職名 |
教授 |
| researchmap研究者コード |
R000011792 |
| researchmap機関 |
岡山理科大学 |
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- 2020/08 Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology Neurol Neuroimmunol Neuroinflamm Fujihara K, Bennett J, de Seze J, Haramura M, Kleiter I, Weinshenker B, Yamamura T. Neurol Neuroimmunol Neuroinflamm
- 2019/06 Neuromyelitis optica spectrum disorder； Patient experience and quality of life Beekman J, Keisler A, Pedraza O, Haramura M, Gianella-Borradori A, Katz E, Ratchford J, Barron G, Cook L, Behne J, Blaschke T, Smith T, Yeaman M. Neurol Neuroimmunol Neuroinflamm
- 2015/05 Identification and purification of target protein using affinity resin bearing a photo-label linker. Mabuchi K, Shimizu T, Haramura M, Tanaka A. Bioorg Med Chem Lett.
- 2011/09 Distinct cell surface proteome profiling by biotin labeling and glycoprotein capturing. Nagano K, Shinkawa T, Kato K, Inomata N, Yabuki N, Haramura M. J Proteomics.
- 2011/03 Integration of proteomic analyses to monitor the activity status of phosphorylation signaling. Nagano K, Shinkawa T, Yabuki N, Mutoh H, Inomata N, Watanabe Y, Ashihara M, Nagahashi S, Ishii N, Aoki Y, Haramura M. J Proteomics.
- 2010/01 Design and synthesis of peptidomimetic factor VIIa inhibitors. Shiraishi T, Kadono S, Haramura M, Kodama H, Ono Y, Iikura H, Esaki T, Koga T, Hattori K, Watanabe Y, Sakamoto A, Yoshihashi K, Kitazawa T, Esaki K, Ohta M, Sato H, Kozono T. Chem Pharm Bull (Tokyo).
- 2010 Selective elution of target protein from affinity resins by a simple reductant with a thiol group. Mabuchi M, Haramura M, Shimizu T, Nishizaki T, Tanaka A. Bioorg Med Chem Lett.
- 2009 A software program for more reliable precursor ion assignation from LC-MS analysis using LTQ ultra zoom scan. Shinkawa T, Nagano K, Inomata N, Haramura M. J Proteomics.
- 2009 Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment. Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M. Proteomics.
- 2009 Structure-based drug design of peptide mimetics containing large P3 moieties as inhibitors of factor Vlla. Shiraishi T, Kadono S, Haramura M, Kodama H, Ono Y, likura H, Esaki T, Koga T, Hattori K, Watanabe Y, Sakamoto A, Yoshihashi K, Kitazawa T, Esaki K, Ohta M, Sato H, Kozono T. Lett. Drug Des. Discovery.
- 2008/08 Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination. Shiraishi T, Kadono S, Haramura M, Kodama H, Ono Y, Iikura H, Esaki T, Koga T, Hattori K, Watanabe Y, Sakamoto A, Yoshihashi K, Kitazawa T, Esaki K, Ohta M, Sato H, Kozono T. Bioorg Med Chem Lett.
- 2007/02 Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors. Wallace DM, Haramura M, Cheng JF, Arrhenius T, Nadzan AM. Bioorg Med Chem Lett.
- 2007 プロテオミクスから創薬へ ―ケミカルバイオロジーの応用と展開― 原村昌幸 日本薬理学雑誌
- 2006/03 Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors. Cheng JF, Chen M, Wallace D, Tith S, Haramura M, Liu B, Mak CC, Arrhenius T, Reily S, Brown S, Thorn V, Harmon C, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM. J Med Chem.
- 2006 Reduction of nonspecific binding proteins to self-assembled monolayer on gold surface. Furuya M, Haramura M, Tanaka A. IF: Bioorg Med Chem.
- 2006 SDS-PAGEゲル内タンパク質を高感度かつ安定的に同定するMSシステム構築の試み 東山喜三彦、土屋耕一、原村昌幸、田中明人 J. Mass Spectrum. Soc. Jpn.
- 2006 Structure of fipexide. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2005/02 Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor. Kadono S, Sakamoto A, Kikuchi Y, Oh-eda M, Yabuta N, Yoshihashi K, Kitazawa T, Suzuki T, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Biochem Biophys Res Commun.
- 2005/01 Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor. Kadono S, Sakamoto A, Kikuchi Y, Oh-eda M, Yabuta N, Yoshihashi K, Kitazawa T, Suzuki T, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Biochem Biophys Res Commun.
- 2005 Peptide mimetic factor Vlla inhibitor: Importance of hydrophilic pocket in S2 site to improve selectivity against thrombin. Kadono S, Sakamoto A, Kikuchi Y, Oh-eda M, Yabuta N, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Esaki T， Sato H, Watanabe Y, ltoh S, Ohta M, Kozono T. Lett. Drug Des. Discovery.
- 2005 Structure of etophylline. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2005 Structure of flurandrenolide. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2005 Structure of guanethidine monosulfate. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2005 Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4. Kadono S, Sakamoto A, Kikuchi Y, Oh-eda M, Yabuta N, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Ono Y, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Acta Crystallogr Sect F Struct Biol Cryst Commun.
- 2005 Structure of nadolol.. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2005 Structure of pimethixene. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2005 Structure of trimetazidine. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online
- 2005 古くて新しいテーマ：アフィニティ樹脂による網羅的ターゲット探索～非特異的蛋白質の抑制～ 原村昌幸、田中明人 ゲノム医学
- 2004 Crystal structure of carisoprodol. Horio K, Tanaka R, Akama H, Haramura M, Tanaka A, Akimoto T, Hirayama N. X-Ray Struct. Anal. Online,
- 2004 Crystal structure of dantrolene. Tanaka R, Akimoto T, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2004 Crystal structure of gefitinib. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2004 Crystal structure of human factor VIIa/tissue factor in complex with peptide mimetic inhibitor. Kadono S, Sakamoto A, Kikuchi Y, Oh-eda M, Yabuta N, Koga T, Hattori K, Shiraishi T, Haramura M, Kodama H, Esaki T, Sato H, Watanabe Y, Itoh S, Ohta M, Kozono T. Biochem Biophys Res Commun.
- 2004 Crystal structure of hydroflumethazide. Tanaka R, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2004 Crystal structure of minoxidil. Akama H, Haramura M, Tanaka A, Akimoto T, Hirayama N. X-Ray Struct. Anal. Online,
- 2004 Crystal structure of nifenazone. Tanaka R, Horio K, Haramura M, Tanaka A, Hirayama N. X-Ray Struct. Anal. Online,
- 2004 Crystal structure of vigabatrin. Haramura M, Tanaka A, Akimoto T, Hirayama N. X-Ray Struct. Anal. Online,
- 2004 Crystal structure of2-(3-carboxypropyl)-6-(4-hydroxyphenyl)-3H-pyridazin-3-ylideneammonium bromide. Tanaka R, Haramura M, Tanaka A, Akimoto T, Hirayama N. X-Ray Struct. Anal. Online,
- 2003/11 Transport of amino acid-based prodrugs by the Na+- and Cl- -coupled amino acid transporter ATB0,+ and expression of the transporter in tissues amenable for drug delivery. Hatanaka T, Haramura M, Fei YJ, Miyauchi S, Bridges CC, Ganapathy PS, Smith SB, Ganapathy V, Ganapathy ME. J Pharmacol Exp Ther.
- 2003 Crystal structure of clobetasol propionate. Haramura M, Tanaka A, Akimoto T, Hirayama N. X-Ray Struct. Anal. Online,
- 2003 Crystal structure of dichlorphenamide. Haramura M, Tanaka A, Akimoto T, Hirayama N. X-Ray Struct. Anal. Online,
- 2003 Crystal structure of streptozocin Haramura M, Tanaka A, Akimoto T, Hirayama N. X-Ray Struct. Anal. Online,
- 2002/06 Design and synthesis of novel tetra-peptide motilin agonists. Haramura M, Tsuzuki K, Okamachi A, Yogo K, Ikuta M, Kozono T, Takanashi H, Murayama E. Bioorg Med Chem
- 2002/01 Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin. Haramura M, Okamachi A, Tsuzuki K, Yogo K, Ikuta M, Kozono T, Takanashi H, Murayama E. J Med Chem
- 2001/04 Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor. Sugano K, Yoshida S, Takaku M, Haramura M, Saitoh R, Nabuchi Y, Ushio H. Bioorg Med Chem Lett
- 2001/01 Design and synthesis of N-terminal cyclic motilin partial peptides: a novel pure motilin antagonist. Haramura M, Okamachi A, Tsuzuki K, Yogo K, Ikuta M, Kozono T, Takanashi H, Murayama E. Chem Pharm Bull (Tokyo)
- 2001 Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2). Han YH, Kato Y, Haramura M, Ohta M, Matsuoka H, Sugiyama Y. Pharm Res
- 1999/11 Structure-activity study of intact porcine motilin. Haramura M, Tsuzuki K, Okamachi A, Yogo K, Ikuta M, Kozono T, Takanashi H, Murayama E. Chem Pharm Bull (Tokyo)
- 1989 Chirarity transfer in the 1,5-hydride shift of stannyl compound having a cationic center at the gamma-position. Sato T, Haramura M, Taka N. Tetrahedron Lett.
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